Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
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DOI：
10.2337/dc10-1265
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发表时间：
2011-01
期刊：
影响因子：
16.2
通讯作者：
DIAGRAM+ Investigators
中科院分区：
文献类型：
--
作者：
de Miguel-Yanes JM;Shrader P;Pencina MJ;Fox CS;Manning AK;Grant RW;Dupuis J;Florez JC;D'Agostino RB Sr;Cupples LA;Meigs JB;MAGIC Investigators;DIAGRAM+ Investigators
测试2型糖尿病遗传变异的知识是否能改善疾病预测。我们使用按年龄分层的汇总logistic回归模型（<50岁，糖尿病病例= 144例;或≥50岁，糖尿病病例= 302例），在3,471名随访超过34年的Fracket Offspring研究受试者中检测了40种与糖尿病相关的单核苷酸多态性（SNP）。模型包括临床风险因素和40-SNP加权遗传风险评分。在<50岁的人群中，临床危险因素模型C-统计量为0.908; 40-SNP评分将其增加到0.911（P = 0.3;净重新分类改善（NRI）：10.2%，P = 0.001）。在年龄≥50岁的人群中，无评分和有评分的C统计量分别为0.883和0.884（P = 0.2; NRI：0.4%）。年龄<50岁的人群中每个风险等位基因的风险高于年龄≥50岁的人群（24%对11%;年龄相互作用的P值= 0.02）。对常见遗传变异的了解适当地将年轻人的2型糖尿病风险重新分类为临床风险因素以外的风险，但老年人则不然。
To test if knowledge of type 2 diabetes genetic variants improves disease prediction. We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (<50 years, diabetes cases = 144; or ≥50 years, diabetes cases = 302). Models included clinical risk factors and a 40-SNP weighted genetic risk score. In people <50 years of age, the clinical risk factors model C-statistic was 0.908; the 40-SNP score increased it to 0.911 (P = 0.3; net reclassification improvement (NRI): 10.2%, P = 0.001). In people ≥50 years of age, the C-statistics without and with the score were 0.883 and 0.884 (P = 0.2; NRI: 0.4%). The risk per risk allele was higher in people <50 than ≥50 years of age (24 vs. 11%; P value for age interaction = 0.02). Knowledge of common genetic variation appropriately reclassifies younger people for type 2 diabetes risk beyond clinical risk factors but not older people.
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影响因子：
30.8
作者：
Zeggini, Eleftheria;Scott, Laura J.;Saxena, Richa;Voight, Benjamin F.;Marchini, Jonathan L.;Hu, Tianle;de Bakker, Paul I. W.;Abecasis, Goncalo R.;Almgren, Peter;Andersen, Gitte;Ardlie, Kristin;Bostroem, Kristina Bengtsson;Bergman, Richard N.;Bonnycastle, Lori L.;Borch-Johnsen, Knut;Burtt, Noel P.;Chen, Hong;Chines, Peter S.;Daly, Mark J.;Deodhar, Parimal;Ding, Chia-Jen;Doney, Alex S. F.;Duren, William L.;Elliott, Katherine S.;Erdos, Michael R.;Frayling, Timothy M.;Freathy, Rachel M.;Gianniny, Lauren;Grallert, Harald;Grarup, Niels;Groves, Christopher J.;Guiducci, Candace;Hansen, Torben;Herder, Christian;Hitman, Graham A.;Hughes, Thomas E.;Isomaa, Bo;Jackson, Anne U.;Jorgensen, Torben;Kong, Augustine;Kubalanza, Kari;Kuruvilla, Finny G.;Kuusisto, Johanna;Langenberg, Claudia;Lango, Hana;Lauritzen, Torsten;Li, Yun;Lindgren, Cecilia M.;Lyssenko, Valeriya;Marvelle, Amanda F.;Meisinger, Christa;Midthjell, Kristian;Mohlke, Karen L.;Morken, Mario A.;Morris, Andrew D.;Narisu, Narisu;Nilsson, Peter;Owen, Katharine R.;Palmer, Colin N. A.;Payne, Felicity;Perry, John R. B.;Pettersen, Elin;Platou, Carl;Prokopenko, Inga;Qi, Lu;Qin, Li;Rayner, Nigel W.;Rees, Matthew;Roix, Jeffrey J.;Sandbaek, Anelli;Shields, Beverley;Sjogren, Marketa;Steinthorsdottir, Valgerdur;Stringham, Heather M.;Swift, Amy J.;Thorleifsson, Gudmar;Thorsteinsdottir, Unnur;Timpson, Nicholas J.;Tuomi, Tiinamaija;Tuomilehto, Jaakko;Walker, Mark;Watanabe, Richard M.;Weedon, Michael N.;Willer, Cristen J.;Illig, Thomas;Hveem, Kristian;Hu, Frank B.;Laakso, Markku;Stefansson, Kari;Pedersen, Oluf;Wareham, Nicholas J.;Barroso, Ines;Hattersley, Andrew T.;Collins, Francis S.;Groop, Leif;McCarthy, Mark I.;Boehnke, Michael;Altshuler, David
通讯作者：
Altshuler, David
新的遗传基因座涉及禁食葡萄糖稳态及其对2型糖尿病风险的影响。
影响因子：
30.8
作者：
通讯作者：
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影响因子：
30.8
作者：
通讯作者：
--
影响因子：
3.5
作者：
Qi, Lu;Cornelis, Marilyn C.;Hu, Frank B.
通讯作者：
Hu, Frank B.
影响因子：
5
作者：
KANNEL, WB;FEINLEIB, M;CASTELLI, WP
通讯作者：
CASTELLI, WP