Metabolic syndrome and carotid intima-media thickness in chronic obstructive pulmonary disease.
Metabolic syndrome and carotid intima-media thickness in chronic obstructive pulmonary disease.
复制标题
DOI：
10.1186/2049-6958-8-61
复制
发表时间：
2013-09-17
影响因子：
2.3
通讯作者：
Yorgancioglu A
中科院分区：
文献类型：
--
作者：
Ozgen Alpaydin A;Konyar Arslan I;Serter S;Sakar Coskun A;Celik P;Taneli F;Yorgancioglu A
本研究的目的是探讨慢性阻塞性肺疾病（COPD）患者代谢综合征（MetS）、颈动脉内膜中层厚度（IMT）和血清C反应蛋白（CRP）水平的患病率以及它们之间可能的关系。该研究包括 50 名稳定的慢性阻塞性肺病患者和 40 名健康对照者。根据吸烟状况，参与者进一步分为四组。对 COPD 患者进行肺功能测试。对所有研究人群进行人体测量和血液化学分析、血清 CRP 水平和颈动脉内膜中层厚度 (IMT) 测量。 COPD 患者代谢综合征的患病率为 43%，对照组为 30%（p = 0.173）。与无 MetS 的患者相比，有 MetS 的 COPD 患者的 FEV1% 和 FEV1/FVC 较高（分别为 p = 0.001 和 p = 0.014）。不同分期的COPD患者MetS患病率存在显着差异（p = 0.017），其中2期患者的MetS患病率最高（59%）。 COPD 患者的颈动脉 IMT 显着高于对照组（分别为 1.07±0.25 mm 和 0.86±0.18 mm；p<0.001）。 COPD 患者和对照组的血清 CRP 水平没有差异，但无论是否存在 COPD，MetS 患者的血清 CRP 水平均高于无 MetS 的患者 (p = 0.02)。研究发现，慢性阻塞性肺病患者的颈动脉 IMT 早期动脉粥样硬化标志物高于健康对照者。据观察，随着气流阻塞严重程度的增加，MetS 患病率下降。因此，即使在没有症状的情况下，对慢性阻塞性肺病患者进行这些心血管危险因素的筛查也将是一种新方法。
The aim of this study is to investigate the prevalence of metabolic syndrome (MetS), carotid intima media thickness (IMT), and serum C-reactive protein (CRP) levels in patients with chronic obstructive pulmonary disease (COPD), and the possible relationships among them. Fifty stable COPD patients and 40 healthy controls were included in the study. The participants were further divided into four groups according to their smoking status. Pulmonary function tests were performed in COPD patients. Anthropometric measurements and blood chemistry analysis, serum CRP levels and carotid intima-media thickness (IMT) measurements were performed in all the study population. Prevalence of metabolic syndrome was 43% in COPD patients and 30% in the control group (p = 0.173). FEV1% and FEV1/FVC were higher in COPD patients with MetS (p = 0.001 and p = 0.014, respectively) compared to those without MetS. Prevalence of MetS was significantly different among the COPD patients with different stages (p = 0.017) with the highest value in stage 2 (59%). Carotid IMT was significantly higher in COPD patients than in control group (1.07 ± 0.25 mm and 0.86 ± 0.18 mm, respectively; p < 0.001). Serum CRP levels were not different in COPD patients and controls, however they were higher in individuals with MetS compared to those without MetS regardless of COPD presence (p = 0.02). Early markers of atherogenesis, in terms of carotid IMT, were found to be higher in COPD patients than in healthy controls. MetS prevalence was observed to decrease as the severity of airflow obstruction increased. Therefore, screening COPD patients for these cardiovascular risk factors would be a novel approach even in absence of symptoms.
登录
查看更多内容
影响因子：
24.3
作者：
Mannino, DM;Watt, G;Vestbo, J
通讯作者：
Vestbo, J
影响因子：
10
作者：
Broekhuizen, R;Wouters, EFM;Schols, AMWJ
通讯作者：
Schols, AMWJ
影响因子：
37.8
作者：
Dekker, JM;Girman, C;Heine, RJ
通讯作者：
Heine, RJ
影响因子：
16.2
作者：
Ford, ES;Giles, WH
通讯作者：
Giles, WH
影响因子：
37.8
作者：
PIGNOLI, P;TREMOLI, E;PAOLETTI, R
通讯作者：
PAOLETTI, R