A single-cell trajectory atlas of striatal development.
A single-cell trajectory atlas of striatal development.
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DOI：
10.1038/s41598-023-36255-5
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发表时间：
2023-06-03
影响因子：
4.6
通讯作者：
Konopka, Genevieve
中科院分区：
文献类型：
--
作者：
Anderson, Ashley G.;Kulkarni, Ashwinikumar;Konopka, Genevieve
The striatum integrates dense neuromodulatory inputs from many brain regions to coordinate complex behaviors. This integration relies on the coordinated responses from distinct striatal cell types. While previous studies have characterized the cellular and molecular composition of the striatum using single-cell RNA-sequencing at distinct developmental timepoints, the molecular changes spanning embryonic through postnatal development at the single-cell level have not been examined. Here, we combine published mouse striatal single-cell datasets from both embryonic and postnatal timepoints to analyze the developmental trajectory patterns and transcription factor regulatory networks within striatal cell types. Using this integrated dataset, we found that dopamine receptor-1 expressing spiny projection neurons have an extended period of transcriptional dynamics and greater transcriptional complexity over postnatal development compared to dopamine receptor-2 expressing neurons. Moreover, we found the transcription factor, FOXP1, exerts indirect changes to oligodendrocytes. These data can be accessed and further analyzed through an interactive website (https://mouse-striatal-dev.cells.ucsc.edu).
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