Associations Between Sleep and Metabolic Outcomes in Preadolescent Children.
Associations Between Sleep and Metabolic Outcomes in Preadolescent Children.
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DOI：
10.1210/jendso/bvac137
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发表时间：
2022-10-11
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
--
作者：
越来越多的证据表明，睡眠对儿童的代谢健康起着重要作用。我们的目的是确定睡眠是如何与胰岛素敏感性，胰岛素分泌，β细胞功能，肥胖（BMI z评分，体脂%，腰围身高比）使用客观测量的睡眠和口服葡萄糖耐量试验（OGTT）衍生的措施。出生于Kaiser Permanente Southern加州的62名7-11岁儿童佩戴腕部加速计7天以客观测量睡眠，完成OGTT，并收集人体测量值（身高[cm]、体重[kg]、腰围[cm]、体脂[%]）。使用线性回归，评估Matsuda胰岛素敏感性指数（ISI）、胰岛素生成指数（IGI）、倾向指数（DI）、BMI z评分、腰围/身高比和体脂%与睡眠参数[总睡眠时间（TST; min）、睡眠效率（SE; %）、卧床时间（TIB; min）、入睡后觉醒（WASO; min）和睡眠潜伏期（SL; min）]之间的相关性。体脂%作为TST与ISI关系的中介变量。较长的TST与较好的胰岛素敏感性相关（P = 0.02），但在调整体脂%后并非如此。睡眠参数与IGI或DI无关。较长的TST与较低的体脂百分比（P = 0.01）和较低的腰高比（P = 0.05）相关。体脂%对TST与ISI关系的解释率为62%（P = 0.01）。较长的TIB与较低的肥胖指标相关（P < 0.05）。SE、WASO或SL与代谢结果之间无相关性。客观测量的睡眠时间与较低的肥胖有关，睡眠时间和ISI之间的关系部分通过青春期前儿童的肥胖水平出现。较长的睡眠时间可能对代谢健康很重要。
Growing evidence suggests an important role for sleep for the metabolic health of children. We aimed to determine how sleep is related to insulin sensitivity, insulin secretion, beta-cell function, and adiposity (BMI z-scores, body fat %, waist to height ratio) using objectively measured sleep and oral glucose tolerance test (OGTT)-derived measures. Sixty-two children aged 7-11 years, born at Kaiser Permanente Southern California, wore wrist accelerometers for 7 days to objectively measure sleep, completed an OGTT, and had anthropometric measures (height [cm], weight [kg], waist [cm], body fat [%]) collected. Using linear regression, associations between Matsuda insulin sensitivity index (ISI), insulinogenic index (IGI), disposition index (DI), BMI z-score, waist to height ratio, and body fat % with sleep parameters [total sleep time (TST; min), sleep efficiency (SE; %), time in bed (TIB; min), wake after sleep onset (WASO; min), and sleep latency (SL; min)] were assessed. Body fat % was tested as a mediator of the relationship between TST and ISI. Longer TST was associated with better insulin sensitivity (P = 0.02), but not after adjusting for body fat %. Sleep parameters were not associated with IGI or DI. Longer TST was associated with lower % body fat (P = 0.01) and lower waist-to-height-ratios (P = 0.05). Body fat % explained 62% (P = 0.01) of the relationship between TST and ISI. Longer TIB was associated with lower adiposity measures (P < 0.05). There were no associations between SE, WASO, or SL and metabolic outcomes. Objectively measured sleep duration was associated with lower adiposity, and the relationship between sleep duration and ISI appeared partly through adiposity levels in preadolescent children. Longer sleep duration may be important for metabolic health.
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影响因子：
7.7
作者：
Buxton OM;Pavlova M;Reid EW;Wang W;Simonson DC;Adler GK
通讯作者：
Adler GK
影响因子：
8
作者：
Hart, Chantelle N.;Carskadon, Mary A.;Wing, Rena
通讯作者：
Wing, Rena
影响因子：
4.5
作者：
Chen MY;Wang EK;Jeng YJ
通讯作者：
Jeng YJ
DOI：
10.1002/oby.21321
发表时间：
2016-01
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Broussard JL;Kilkus JM;Delebecque F;Abraham V;Day A;Whitmore HR;Tasali E
通讯作者：
Tasali E
影响因子：
4.4
作者：
Berentzen, Nina E.;Smit, Henriette A.;Wijga, Alet H.
通讯作者：
Wijga, Alet H.