Pore formation in lipid membrane II: Energy landscape under external stress.
Pore formation in lipid membrane II: Energy landscape under external stress.
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DOI：
10.1038/s41598-017-12749-x
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发表时间：
2017-10-02
影响因子：
4.6
通讯作者：
Batishchev OV
中科院分区：
文献类型：
--
作者：
Akimov SA;Volynsky PE;Galimzyanov TR;Kuzmin PI;Pavlov KV;Batishchev OV
脂质膜是非常稳定的包膜，允许细胞在各种环境中存活并保持所需的内部组成。通过形成横向孔的膜渗透需要大量的外部应力。实际上，孔通常通过施加横向张力或跨膜电压形成。使用与前一篇文章中用于获得无应力膜中孔形成的连续轨迹相同的方法，我们现在考虑外部应力下的孔形成过程。孔隙形成的等待时间证明了横向张力的非单调函数，从零张力的无穷大下降到每米几毫牛顿的张力的最小值。相反，跨膜电压引起等待时间单调下降。孔形成轨迹的几种脂质不同的自发曲率和弹性模量在各种外部条件下的分析提供了一些实验观察到的现象的机制的工具的见解。
Lipid membranes are extremely stable envelopes allowing cells to survive in various environments and to maintain desired internal composition. Membrane permeation through formation of transversal pores requires substantial external stress. Practically, pores are usually formed by application of lateral tension or transmembrane voltage. Using the same approach as was used for obtaining continuous trajectory of pore formation in the stress-less membrane in the previous article, we now consider the process of pore formation under the external stress. The waiting time to pore formation proved a non-monotonous function of the lateral tension, dropping from infinity at zero tension to a minimum at the tension of several millinewtons per meter. Transmembrane voltage, on the contrary, caused the waiting time to decrease monotonously. Analysis of pore formation trajectories for several lipid species with different spontaneous curvatures and elastic moduli under various external conditions provided instrumental insights into the mechanisms underlying some experimentally observed phenomena.
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影响因子：
8.6
作者：
Galimzyanov TR;Molotkovsky RJ;Bozdaganyan ME;Cohen FS;Pohl P;Akimov SA
通讯作者：
Akimov SA
影响因子：
8.6
作者：
Betterton, MD;Brenner, MP
通讯作者：
Brenner, MP
影响因子：
64.8
作者：
ISRAELACHVILI, J;PASHLEY, R
通讯作者：
PASHLEY, R
影响因子：
2.4
作者：
Karal, Mohammad Abu Sayem;Levadnyy, Victor;Yamazaki, Masahito
通讯作者：
Yamazaki, Masahito
影响因子：
0.1
作者：
Akimov, S. A.;Mukovozov, A. A.;Batishchev, O. V.
通讯作者：
Batishchev, O. V.