Evaluating the Effects of Varenicline on Craving, Withdrawal, and Affect in a Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Varenicline for Smokeless Tobacco Dependence in India.
Evaluating the Effects of Varenicline on Craving, Withdrawal, and Affect in a Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Varenicline for Smokeless Tobacco Dependence in India.
复制标题
在印度进行的瓦伦尼克兰治疗无烟烟草依赖的随机、双盲、安慰剂对照临床试验中评估瓦伦尼克兰对渴望、戒断和影响的影响。
DOI：
10.1080/02791072.2015.1075092
复制
发表时间：
2015
影响因子：
2.8
通讯作者：
Schnoll,RobertA
中科院分区：
文献类型：
--
作者：
Jhanjee,Sonali;Jain,Raka;Jain,Veena;Gupta,Tina;Mittal,Swati;Goelz,Patricia;Schnoll,RobertA
This study examined changes in tobacco craving, withdrawal, and affect as correlates of efficacy in a phase-2 clinical trial of varenicline for smokeless tobacco dependence in India. Smokeless tobacco users (N = 237) at the All India Institute of Medical Sciences were randomized to placebo or varenicline. Abstinence was defined as cotinine-verified seven-day point prevalence cessation at end of treatment (EOT). General Linear Model repeated measures assessed the effects of treatment condition, time, abstinence state, and interaction effects on changes in craving, withdrawal, positive (PA) and negative affect (NA) from baseline to EOT. All participants showed a significant reduction in withdrawal (p < .001), total craving (p < .001), positive reinforcement (PR) craving (p < .001), and NA (p = .02), and an increase in PA (p = .04) from baseline to EOT. However, there were no differences between placebo and varenicline participants in measures of withdrawal, craving, or affect from baseline to week 3 or at EOT. Significant interactions between time and abstinence state were found for total craving (p = .008), PR craving (p < .001), and withdrawal (p = .001), indicating reductions in these processes among those abstinent vs. those still chewing smokeless tobacco. Additional research is needed concerning the effects of varenicline on craving, withdrawal, and affect among smokeless tobacco users.
登录
查看更多内容
猕猴补充运动区损伤后的神经缺陷。
DOI：
--
发表时间：
1955
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Ann Marie Travis
通讯作者：
Ann Marie Travis
猴内侧丘脑核皮质投射的限制和组织
影响因子：
2.5
作者：
K. Pribram;K. Chow;J. Semmes
通讯作者：
J. Semmes
影响因子：
14.5
作者：
FLOWERS, K
通讯作者：
FLOWERS, K
影响因子：
2.5
作者：
JONES, EG;COULTER, JD;PORTER, R
通讯作者：
PORTER, R
DOI：
10.1523/jneurosci.04-02-00539.1984
发表时间：
1984-02
期刊：
--
影响因子：
--
作者：
G. Schell;P. Strick
通讯作者：
G. Schell;P. Strick