Behavioral analysis of circadian rhythms: Entraining the circadian clock and determining the food-entrainable oscillator mechanism
Behavioral analysis of circadian rhythms: Entraining the circadian clock and determining the food-entrainable oscillator mechanism
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昼夜节律的行为分析：诱导生物钟并确定食物诱导的振荡机制
DOI：
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
W. Nakamura
中科院分区：
文献类型：
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作者：
W. Nakamura
昼夜节律是由内部生物钟调节的行为和生理功能的振荡。在哺乳动物中，昼夜节律可以在下丘脑视交叉上核（SCN）中得到最好的研究。SCN被认为是昼夜节律的主时钟。SCN病变取消昼夜节律和移植的SCN恢复的行为节奏，这些研究结果证实了SCN作为昼夜节律起搏器的作用。最近发现的昼夜节律振荡的分子机制使我们能够检查基因操纵，分子钟缺陷的小鼠，这些动物模型的使用增强了我们对生物钟的理解。据报道，在时间限制的进食条件下，进食前运动活动表现出昼夜节律的定义特征。预喂食活动由与SCN不同的机制驱动。尽管对损伤策略进行了广泛的研究，但尚未确定食物可消化振荡器的解剖位置。此外，最近使用分子钟缺陷小鼠的研究表明，已知的昼夜节律钟对于进食前活动的出现是不确定的。因此，单独检查进食前活动是不够的，进一步检查进食前活动节律的昼夜振荡特性对于理解食物可消化的昼夜节律是必不可少的。
Circadian rhythms are oscillations in behavior and physiological functions that are regulated by internal biological clocks. In mammals, the circadian rhythms can be best studied in the hypothalamic suprachiasmatic nucleus (SCN). The SCN has been considered as the master clock of circadian rhythms. SCN lesions abolish the circadian rhythms and transplantation of the SCN restores the behavioral rhythm; these findings confirm the role of the SCN as a circadian pacemaker. Recent discovery of molecular machineries of circadian oscillation enables us to examine genetically manipulated, molecular-clock-deficient mice, and use of these animal models has enhanced our understanding of biological clocks. It has been reported that prefeeding locomotor activity under a temporal restricted feeding condition exhibits the defining characteristic of a circadian rhythm. The prefeeding activity is driven by a distinct mechanism from the SCN. Despite extensive studies performed with the lesion strategy, the anatomic location of the food-entrainable oscillator has not been determined. Furthermore, recent studies using molecular-clock deficient mice reveal that the known circadian clock is dispensable for appearance of the prefeeding activity. Thus, examining the prefeeding activity alone is not sufficient and further examination for circadian oscillatory properties of the prefeeding activity rhythm is essential for understanding the food-entrainable circadian rhythms.
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DOI：
10.1073/pnas.96.21.12114
发表时间：
1999-10-12
影响因子：
11.1
作者：
Vitaterna, MH;Selby, CP;Sancar, A
通讯作者：
Sancar, A
影响因子：
56.9
作者：
RALPH, MR;MENAKER, M
通讯作者：
MENAKER, M
影响因子：
56.9
作者：
VITATERNA, MH;KING, DP;TAKAHASHI, JS
通讯作者：
TAKAHASHI, JS
影响因子：
56.9
作者：
RALPH, MR;FOSTER, RG;MENAKER, M
通讯作者：
MENAKER, M
影响因子：
56.9
作者：
Lowrey, PL;Shimomura, K;Takahashi, JS
通讯作者：
Takahashi, JS