A novel vaccine adjuvant based on straight polyacrylate potentiates vaccine-induced humoral and cellular immunity in cynomolgus macaques.
A novel vaccine adjuvant based on straight polyacrylate potentiates vaccine-induced humoral and cellular immunity in cynomolgus macaques.
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DOI：
10.1080/21645515.2020.1855956
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发表时间：
2021-07-03
影响因子：
4.8
通讯作者：
Haensler J
中科院分区：
文献类型：
--
作者：
Pavot V;Bisceglia H;Guillaume F;Montano S;Zhang L;Boudet F;Haensler J
佐剂对亚单位疫苗的效力至关重要。尽管在过去十年中，几种新的佐剂已被批准用于人类疫苗，但获得许可的人类疫苗中的佐剂组仍然很小。仍然需要可以安全地用于人类、易于来源和与广泛的抗原一起配制并且将广泛适用于广泛的疫苗的新型佐剂。在这篇文章中，使用赛诺菲开发的呼吸道合胞病毒（RSV）纳米颗粒融合前F模型抗原，我们在猕猴模型中证明了基于聚丙烯酸酯（PAA）的佐剂SPA 09具有良好的耐受性，并增加了疫苗抗原特异性体液免疫（持续中和抗体，记忆B细胞和粘膜免疫）并以剂量依赖性方式引发强烈的TH 1型反应（基于IFNγ和IL-2 ELISpot）。这些数据保证了SPA 09佐剂的进一步开发，用于临床试验中的评估。
Adjuvants are central to the efficacy of subunit vaccines. Although several new adjuvants have been approved in human vaccines over the last decade, the panel of adjuvants in licensed human vaccines remains small. There is still a need for novel adjuvants that can be safely used in humans, easy to source and to formulate with a wide range of antigens and would be broadly applicable to a wide range of vaccines. In this article, using the Respiratory Syncytial Virus (RSV) nanoparticulate prefusion F model antigen developed by Sanofi, we demonstrate in the macaque model that the polyacrylate (PAA)-based adjuvant SPA09 is well tolerated and increases vaccine antigen-specific humoral immunity (sustained neutralizing antibodies, memory B cells and mucosal immunity) and elicits strong TH1-type responses (based on IFNγ and IL-2 ELISpots) in a dose-dependent manner. These data warrant further development of the SPA09 adjuvant for evaluation in clinical trials.
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影响因子：
2.8
作者：
Dennehy R;McClean S
通讯作者：
McClean S
影响因子：
4.6
作者：
Knudsen NP;Olsen A;Buonsanti C;Follmann F;Zhang Y;Coler RN;Fox CB;Meinke A;D'Oro U;Casini D;Bonci A;Billeskov R;De Gregorio E;Rappuoli R;Harandi AM;Andersen P;Agger EM
通讯作者：
Agger EM
影响因子：
2.2
作者：
Mustafaev, MI;Yucel, F;Bermek, E
通讯作者：
Bermek, E
影响因子：
6.2
作者：
Andrianov, AK;Marin, A;Chen, JP
通讯作者：
Chen, JP
影响因子：
4.9
作者：
Cayatte, Corinne;Marin, Alexander;Andrianov, Alexander K.
通讯作者：
Andrianov, Alexander K.