High salt diet down-regulates proximal tubule Na+, K(+)-ATPase activity in Dahl salt-resistant but not in Dahl salt-sensitive rats: evidence of defective dopamine regulation.
High salt diet down-regulates proximal tubule Na+, K(+)-ATPase activity in Dahl salt-resistant but not in Dahl salt-sensitive rats: evidence of defective dopamine regulation.
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高盐饮食下调 Dahl 盐抗性大鼠的近端小管 Na , K( )-ATP 酶活性，但不会下调 Dahl 盐敏感大鼠：多巴胺调节缺陷的证据。
DOI：
10.1111/j.1748-1716.1992.tb09295.x
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Anita Aperia
中科院分区：
文献类型：
--
作者：
A. Nishi;A. Bertorello;Anita Aperia
我们检测了高盐饮食对高血压前盐敏感和盐抵抗大鼠近端小管段Na+，K(+)- atp酶活性的调节。大鼠分别饲喂正常盐或高盐饮食（0.9%盐水作为饮用水）。在正常盐饮食中，Na+，K(+)- atp酶活性在达尔盐敏感大鼠和耐盐大鼠之间没有差异。高盐喂养2 d和10 d后，达尔耐盐大鼠体内Na+、K(+)- atp酶活性显著低于正常盐喂养的达尔耐盐大鼠（P < 0.01）。高盐饮食对达尔盐耐盐大鼠的Na+，K(+)- atp酶活性的降低可以通过芳香l -氨基酸脱羧酶（多巴胺合成酶）抑制剂benserazide来逆转。相反，Na+，K(+)- atp酶活性在高盐饮食中没有降低，benserazide对Dahl盐敏感大鼠Na+，K(+)- atp酶活性没有影响。这些结果表明，Dahl盐敏感大鼠在高盐饮食中不具有下调近端小管Na+，K(+)- atp酶活性的能力。间接证据表明，局部产生的多巴胺对Na+，K(+)- atp酶活性的调节在达尔盐敏感大鼠中不存在。
We examined the regulation of Na+,K(+)-ATPase activity in proximal tubule segments during a high salt diet in prehypertensive Dahl salt-sensitive and salt-resistant rats. Rats were placed on normal salt or high salt diets (0.9% saline as drinking water). During the normal salt diet, Na+,K(+)-ATPase activity was not different between Dahl salt-sensitive and salt-resistant rats. After 2 days and 10 days on a high salt diet, Na+,K(+)-ATPase activity in Dahl salt-resistant rats significantly decreased when compared to Dahl salt-resistant rats on a normal salt diet (P less than 0.01). The decreased Na+,K(+)-ATPase activity in Dahl salt-resistant rats during a high salt diet was reversed by treatment with an inhibitor of aromatic L-amino acid decarboxylase (dopamine synthesizing enzyme), benserazide. In contrast, Na+,K(+)-ATPase activity did not decrease during the high salt diet and benserazide had no effect on Na+,K(+)-ATPase activity in Dahl salt-sensitive rats. These results indicate that Dahl salt-sensitive rats do not have the capacity to down-regulate the proximal tubule Na+,K(+)-ATPase activity during a high salt diet. Indirect evidence suggests that the regulation of Na+,K(+)-ATPase activity by locally produced dopamine is absent in Dahl salt-sensitive rats.
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DOI：
10.1152/ajprenal.1990.258.1.f52
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
--
作者：
I. Seri;B. Kone;S. Gullans;A. Aperia;B. Brenner;B. Ballermann
通讯作者：
I. Seri;B. Kone;S. Gullans;A. Aperia;B. Brenner;B. Ballermann
影响因子：
15.9
作者：
KINOSHITA, S;SIDHU, A;FELDER, RA
通讯作者：
FELDER, RA
Dahl 大鼠中 Na , K( )-ATPase α 1 位点的等位基因未能与血压共分离。
影响因子：
4.9
作者：
Rapp,JP;Dene,H
通讯作者：
Dene,H
DOI：
10.1152/ajprenal.1986.251.1.f57
发表时间：
1986-07
期刊：
The American journal of physiology
影响因子：
--
作者：
R. Roman
通讯作者：
R. Roman
清醒 Dahl S 和 R 大鼠的肾功能和钠平衡。
DOI：
10.1152/ajpregu.1987.252.5.r833
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
Roman,RJ;Osborn,JL
通讯作者：
Osborn,JL