A Critical Role for the Paraventricular Nucleus of the Hypothalamus in the Regulation of the Volume Reflex in Normal and Various Cardiovascular Disease States.
A Critical Role for the Paraventricular Nucleus of the Hypothalamus in the Regulation of the Volume Reflex in Normal and Various Cardiovascular Disease States.
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DOI：
10.1007/s11906-022-01187-4
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发表时间：
2022-07
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
本文综述了前脑神经通路和神经调节系统，特别是下丘脑室旁核内的一氧化氮系统在调节神经体液驱动、自主神经通路和液体平衡方面的研究进展。来自高血压和心力衰竭实验模型的动物以及患有高血压的人类的越来越多的证据表明，中枢神经通路的改变，特别是在神经元一氧化氮调节的PVN神经内，参与调节交感神经流出，特别是到肾脏，导致在高血压和心力衰竭状态下常见的液体平衡的改变。高血压和心力衰竭状态的特征包括室旁核内神经元一氧化氮的变化，导致肾交感神经活动增加，从而导致这些疾病中的钠和液体滞留。全面了解这些机制将提高我们更有效地治疗高血压和心力衰竭及其心血管并发症的能力。
This review focuses on studies implicating forebrain neural pathways and neuromodulator systems, particularly the nitric oxide system within the paraventricular nucleus of the hypothalamus in regulating neurohumoral drive, autonomic pathways and fluid balance. Accumulating evidence from animals with experimental models of hypertension and heart failure as well as humans with hypertension suggests that alterations in central neural pathways, particularly within the PVN neuromodulated by neuronal nitric oxide are involved in regulating sympathetic outflow particularly to the kidney resulting in alterations in fluid balance commonly observed in hypertension and heart failure states. The characteristics of the hypertensive and heart failure states include alterations in neuronal nitric oxide within the PVN to cause an increase in renal sympathetic nerve activity to result in sodium and fluid retention in these diseases. A comprehensive understanding of these mechanisms will enhance our ability to treat hypertensive and heart failure conditions and their cardiovascular complications more efficiently.
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影响因子：
12.3
作者：
Collins, HL;Rodenbaugh, DW;DiCarlo, SE
通讯作者：
DiCarlo, SE
DOI：
10.1152/ajpregu.00058.2008
发表时间：
2009-07-01
影响因子：
2.8
作者：
Frithiof, Robert;Ramchandra, Rohit;Rundgren, Mats
通讯作者：
Rundgren, Mats
影响因子：
3.3
作者：
Badoer, E;McKinlay, D;McGrath, BP
通讯作者：
McGrath, BP
影响因子：
2.5
作者：
Chen, Qing-Hui;Toney, Glenn M.
通讯作者：
Toney, Glenn M.
DOI：
10.1152/ajpheart.1997.273.6.h2613
发表时间：
1997-12-01
影响因子：
4.8
作者：
Collins, HL;DiCarlo, SE
通讯作者：
DiCarlo, SE