Melatonin facilitates extinction, but not acquisition or expression, of conditional cued fear in rats.
Melatonin facilitates extinction, but not acquisition or expression, of conditional cued fear in rats.
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褪黑素促进大鼠条件暗示恐惧的消除，但不促进其获得或表达
DOI：
10.1186/1471-2202-15-86
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发表时间：
2014-07-15
期刊：
影响因子：
2.4
通讯作者：
Li CQ
中科院分区：
文献类型：
--
作者：
Huang F;Yang Z;Liu X;Li CQ
之前的研究表明，褪黑激素参与了学习和记忆的过程。在本研究中，我们测试了外源性褪黑素（2.5 mg/kg）对大鼠线索恐惧获得、表达和消退的影响。结果：在条件反射前30分钟进行一次下午给药对线索恐惧的习得没有影响。在消退训练前30分钟注射褪黑素的大鼠在消退训练和消退测试阶段的冻结反应均明显低于注射对照剂的大鼠，但在消退训练的前4个试验中，冻结反应没有差异。消退训练后立即注射褪黑素对消退学习无效。结论在本研究中使用的剂量下，褪黑素在不影响条件暗示恐惧的获得和表达的情况下促进了条件暗示恐惧的消退，而褪黑素只有在消退训练中才促进了条件暗示恐惧的消退。这些发现扩展了之前关于褪黑素对学习和记忆影响的研究，并表明褪黑素可能作为一种治疗创伤后应激障碍（PTSD）等焦虑症的药物。
BackgroundPrevious studies have shown that melatonin is involved in the processes that contribute to learning and memory. At present study, we tested the effects of exogenous melatonin (2.5 mg/kg) on the acquisition, expression and extinction of cued fear in rats.ResultsResults showed that a single afternoon administration 30 min before conditioning has no effect on the acquisition of cued fear. Compared to rats injected with vehicle, rats injected with melatonin 30 min before extinction training presented a significant lower freezing during both extinction training and extinction test phases, however, freezing response did not differ for the initial four trials during extinction training. Melatonin injected immediately after extinction training was ineffective on extinction learning.ConclusionsThese results suggest that melatonin, at the dose applied in this study, facilitates the extinction of conditional cued fear without affecting its acquisition or expression, and melatonin facilitates cued fear extinction only when it is present during extinction training. These findings extend previous research on the melatonin effects on learning and memory and suggest that melatonin may serve as an agent for the treatment of anxiety disorders such as posttraumatic stress disorder (PTSD).
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影响因子：
2.4
作者：
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通讯作者：
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作者：
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通讯作者：
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