Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection.
Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection.
复制标题
DOI：
10.1093/infdis/jis033
复制
发表时间：
2012-04-01
期刊：
影响因子：
--
通讯作者：
Ng LF
中科院分区：
文献类型：
--
作者：
Kam YW;Simarmata D;Chow A;Her Z;Teng TS;Ong EK;Rénia L;Leo YS;Ng LF
基孔肯雅病毒（CHIKV）和相关的虫媒病毒是造成大规模流行病爆发的原因，并造成严重的经济和社会影响。虽然感染者从血液中清除了病毒，但有些人会出现衰弱和长期的关节痛。方法：我们在一项针对CHIKV感染患者的纵向研究中调查了抗体反应的特异性和强度，并分析了它们与病毒载量、细胞因子谱和严重程度的相关性。 结果：我们发现CHIKV特异性反应主要由免疫球蛋白G3（IgG3）抗体控制。 抗体是中和性的，并且具有高病毒血症的患者迅速产生高水平的这种特异性同种型的抗CHIKV抗体。尽管这些患者在急性病毒血症阶段经历了更严重的疾病进展，但他们更快地清除了病毒，并且没有经历持续性关节痛。然而，在后期出现IgG3的低病毒血症患者中观察到显著的持续性关节痛。结论：因此，早期CHIKV特异性IgG3的缺失可能作为疾病风险增加患者的特异性标志物。
Background. Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. Although infected individuals clear the virus from the blood, some develop debilitating and prolonged arthralgia. Methods. We investigated specificity and strength of antibody responses in a longitudinal study on CHIKV-infected patients and analyzed their association with viral load, cytokine profile, and severity. Results. We found that CHIKV-specific response is dominated by immunoglobulin G3 (IgG3) antibodies. The antibodies were neutralizing, and patients with high viremia rapidly developed high levels of anti-CHIKV antibodies of this specific isotype. Although these patients endured a more severe disease progression during the acute viremic phase, they cleared the virus faster and did not experience persistent arthralgia. However, significant persistent arthralgia was observed in patients with low viremia who developed IgG3 at a later stage. Conclusions. Absence of early CHIKV-specific IgG3 may therefore serve as a specific marker of patients with increased risk of disease.
登录
查看更多内容
影响因子：
1.6
作者：
Simon, Fabrice;Parola, Philippe;Tolou, Hugues
通讯作者：
Tolou, Hugues
DOI：
10.1093/infdis/jiq042
发表时间：
2011-01-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Chow A;Her Z;Ong EK;Chen JM;Dimatatac F;Kwek DJ;Barkham T;Yang H;Rénia L;Leo YS;Ng LF
通讯作者：
Ng LF
DOI：
10.1016/0035-9203(55)90080-8
发表时间：
1955-01-01
影响因子：
2.2
作者：
ROBINSON, M C
通讯作者：
ROBINSON, M C
DOI：
10.1016/s0928-0197(97)10007-1
发表时间：
1997-11-01
期刊：
CLINICAL AND DIAGNOSTIC VIROLOGY
影响因子：
--
作者：
Narita, M;Yamada, S;Kikuta, H
通讯作者：
Kikuta, H
影响因子：
4.4
作者：
Hoarau, Jean-Jacques;Bandjee, Marie-Christine Jaffar;Gasque, Philippe
通讯作者：
Gasque, Philippe