Detecting COVID-19 from Breath: A Game Changer for a Big Challenge.
Detecting COVID-19 from Breath: A Game Changer for a Big Challenge.
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DOI：
10.1021/acssensors.1c00312
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发表时间：
2021-04-23
期刊：
影响因子：
8.9
通讯作者：
Garoli D
中科院分区：
文献类型：
--
作者：
Giovannini G;Haick H;Garoli D
2019冠状病毒病（COVID-19）可能是过去12个月最常听到的词。这种病毒（SARS-CoV-2）的爆发正在严重危害全球医疗保健系统，社会行为和每个人的生活。COVID-19的早期诊断和阳性病例的隔离已被证明是遏制感染传播的基础。尽管基于聚合酶链反应（PCR）的方法仍然是SARS-CoV-2检测的金标准，但对快速和大规模诊断的迫切需求促使了替代诊断方法的发展。全世界每天进行的数百万次检测仍然不足以实现预期目标，即在日常生活中对人群进行筛查。持续监测COVID-19传播的最有吸引力的方法可能是从呼出气体中直接检测SARS-CoV-2。例如，将可靠、高灵敏度和具有成本效益的检测方法纳入口罩的挑战可能代表着便携式和非侵入性COVID-19护理点诊断发展的突破。在这篇前瞻性论文中，我们讨论了呼吸分析在病毒感染诊断中应用的关键技术方面。我们认为，如果实现这一目标，它将在遏制大流行病蔓延方面改变游戏规则。
Coronavirus disease 2019 (COVID-19) is probably the most commonly heard word of the last 12 months. The outbreak of this virus (SARS-CoV-2) is strongly compromising worldwide healthcare systems, social behavior, and everyone’s lives. The early diagnosis of COVID-19 and isolation of positive cases has proven to be fundamental in containing the spread of the infection. Even though the polymerase chain reaction (PCR) based methods remain the gold standard for SARS-CoV-2 detection, the urgent demand for rapid and wide-scale diagnosis precipitated the development of alternative diagnostic approaches. The millions of tests performed every day worldwide are still insufficient to achieve the desired goal, that of screening the population during daily life. Probably the most appealing approach to consistently monitor COVID-19 spread is the direct detection of SARS-CoV-2 from exhaled breath. For instance, the challenging incorporation of reliable, highly sensitive, and cost-efficient detection methods in masks could represent a breakthrough in the development of portable and noninvasive point-of-care diagnosis for COVID-19. In this perspective paper, we discuss the critical technical aspects related to the application of breath analysis in the diagnosis of viral infection. We believe that, if achieved, it could represent a game-changer in containing the pandemic spread.
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