Cell therapy approaches for lung diseases: current status.
Cell therapy approaches for lung diseases: current status.
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DOI：
10.1016/j.coph.2009.03.002
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发表时间：
2009-06
影响因子：
4
通讯作者：
Weiss, Daniel J.
中科院分区：
文献类型：
--
作者：
Sueblinvong, Viranuj;Weiss, Daniel J.
最近的发现表明，胚胎干细胞和来自成人组织的干细胞，包括骨髓和脐带血，可以用于修复和再生受损或患病的肺。这是一个令人兴奋和快速发展的领域，有望成为各种肺部疾病的治疗方法。虽然最初的重点是干细胞在肺内的植入，但最近的研究表明，在包括急性肺损伤和肺纤维化在内的小鼠肺部疾病模型中，间充质干细胞(MSCs)可以调节局部炎症和免疫反应。此外，根据对克罗恩病或移植物抗宿主病患者使用同种异体骨髓间充质干细胞的安全性和有效性的初步报道，最近已经启动了一项试验，以研究骨髓间充质干细胞对慢性阻塞性肺疾病患者的影响。值得注意的是，最近的几项临床试验表明，在肺动脉高压患者中应用自体干细胞具有潜在的好处。在这篇综述中，我们将介绍细胞治疗的最新进展，重点是间充质干细胞及其在肺发育和修复中的潜在作用。
Recent findings suggest that embryonic stem cells and stem cells derived from adult tissues, including bone marrow and umbilical cord blood, could be utilized in repair and regeneration of injured or diseased lungs. This is an exciting and rapidly moving field that holds promise as a therapeutic approach for variety of lung diseases. Although initial emphasis was on engraftment of stem cells in lung, more, recent studies demonstrate that mesenchymal stem cells (MSCs) can modulate local inflammatory and immune responses in mouse lung disease models including acute lung injury and pulmonary fibrosis. Further, based on initial reports of safety and efficacy following allogeneic administration of MSCs to patients with Crohn’s disease or with graft-versus-host disease, a recent trial has been initiated to study the effect of MSCs in patients with chronic obstructive pulmonary disease. Notably, several recent clinical trials have demonstrated potential benefit of autologous stem cell administration in patient with pulmonary hypertension. In this review, we will describe recent advances in cell therapy with the focus on MSCs and their potential roles in lung development and repair.
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影响因子：
4.1
作者：
Mondrinos, Mark J.;Koutzaki, Sirma H.;Finck, Christine M.
通讯作者：
Finck, Christine M.
影响因子：
4.4
作者：
Gupta, Naveen;Su, Xiao;Matthay, Michael A.
通讯作者：
Matthay, Michael A.
DOI：
10.1513/pats.200802-022aw
发表时间：
2008-08-15
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Nichols, Joan E;Cortiella, Joaquin
通讯作者：
Cortiella, Joaquin
影响因子：
4
作者：
MacPherson, H;Keir, P;Dorin, J
通讯作者：
Dorin, J
影响因子：
4.8
作者：
Quesenberry, Peter J.;Aliotta, Jason M.
通讯作者：
Aliotta, Jason M.