Phasic nucleus accumbens dopamine release encodes effort- and delay-related costs.
Phasic nucleus accumbens dopamine release encodes effort- and delay-related costs.
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DOI：
10.1016/j.biopsych.2010.03.026
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发表时间：
2010-08-01
影响因子：
10.6
通讯作者：
Carelli, Regina M.
中科院分区：
文献类型：
--
作者：
Day, Jeremy J.;Jones, Joshua L.;Wightman, R. Mark;Carelli, Regina M.
最佳决策要求生物体正确评估潜在选择的成本和收益。伏隔核（NAc）内的多巴胺传递与奖励学习和决策制定密切相关，但尚不清楚多巴胺的释放如何有助于涉及成本的决策。基于成本的决策在经过训练的老鼠中进行了检查，这些老鼠被训练将视觉线索与立即或延迟奖励（延迟操纵）或低努力或高努力奖励（努力操纵）联系起来。训练后，使用快速扫描循环伏安法快速监测 NAc 内的多巴胺浓度。与同等程度的延迟或高努力奖励相比，动物表现出对立即或低努力奖励的偏好。奖励预测线索（而非响应执行或奖励交付）会引起 NAc 多巴胺浓度的增加。当只有一种反应选项可用时，提示诱发的多巴胺释放反映了未来奖励的价值，多巴胺的较大增加表明奖励价值更高。相比之下，当同时提出两个选项时，多巴胺会发出两个选项中更好的信号，无论未来的选择如何。 NAc 中的阶段性多巴胺信号反映了两种不同类型的奖励成本并编码潜力，而不是选择情况下的选择值。
Optimal decision making requires that organisms correctly evaluate both the costs and benefits of potential choices. Dopamine transmission within the nucleus accumbens (NAc) has been heavily implicated in reward learning and decision making, but it is unclear how dopamine release may contribute to decisions that involve costs. Cost-based decision making was examined in rats trained to associate visual cues with either immediate or delayed rewards (delay manipulation) or low effort or high effort rewards (effort manipulation). After training, dopamine concentration within the NAc was monitored on a rapid timescale using fast-scan cyclic voltammetry. Animals exhibited a preference for immediate or low effort rewards over delayed or high effort rewards of equal magnitude. Reward-predictive cues, but not response execution or reward delivery, evoked increases in NAc dopamine concentration. When only one response option was available, cue-evoked dopamine release reflected the value of the future reward, with larger increases in dopamine signaling higher value rewards. In contrast, when both options were presented simultaneously, dopamine signaled the better of two options, regardless of the future choice. Phasic dopamine signals in the NAc reflect two different types of reward cost and encode potential rather than chosen value under choice situations.
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影响因子：
25
作者：
Morris, Genela;Nevet, Alon;Bergman, Hagai
通讯作者：
Bergman, Hagai
影响因子：
10.6
作者：
Scheres, Anouk;Tontsch, Chandra;Kaczkurkin, Antonia
通讯作者：
Kaczkurkin, Antonia
中断多巴胺对未来奖励编码的可取消成本和利益编码。
影响因子：
25
作者：
Gan JO;Walton ME;Phillips PE
通讯作者：
Phillips PE
DOI：
10.1523/jneurosci.4515-08.2009
发表时间：
2009-04-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Croxson PL;Walton ME;O'Reilly JX;Behrens TE;Rushworth MF
通讯作者：
Rushworth MF
影响因子：
56.9
作者：
Fiorillo, CD;Tobler, PN;Schultz, W
通讯作者：
Schultz, W