Anterior cingulate cortex γ-aminobutyric acid deficits in youth with depression.
Anterior cingulate cortex γ-aminobutyric acid deficits in youth with depression.
复制标题
患有抑郁症的青少年前扣带皮层 γ-氨基丁酸缺乏。
DOI：
10.1038/tp.2017.187
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发表时间：
2017-08-22
影响因子：
6.8
通讯作者：
Shungu DC
中科院分区：
文献类型：
--
作者：
Gabbay V;Bradley KA;Mao X;Ostrover R;Kang G;Shungu DC
异常低的γ-氨基丁酸（GABA）水平一直报告在成人重度抑郁症（MDD）。我们的研究小组将这一发现扩展到青少年，并记录了GABA缺陷与快感缺乏有关。在这里，我们的目的是证实我们先前的发现，减少大脑GABA在青年抑郁症，并探讨其与临床变量的关联。研究对象为44名无精神药物治疗的MDD青年和36名健康对照（HC）参与者（12-21岁）。参与者代表了39名新招募的青年（MDD=24）和41名来自我们先前报告的研究（MDD=20）的青年的组合样本。GABA水平和谷氨酸和谷氨酰胺（Glx）的组合共振在体内前扣带皮层使用质子磁共振波谱测量。青年抑郁症表现出显着较低的GABA水平比HC在新报告（P=0.003）和合并（P=0.003）的样本。当抑郁的参与者进行分类的基础上存在的快感缺乏，只有快感缺乏MDD亚组表现出减少GABA水平相比，HC（P=0.002）。虽然在新样本中任何临床指标与GABA或Glx水平之间没有相关性，但在合并MDD组中，GABA仅与快感缺乏严重程度呈负相关。此外，在合并样本中，分层回归模型显示，快感缺乏，但不是抑郁症的严重程度，焦虑或自杀，GABA水平的显着差异。这份报告巩固了在MDD过程中早期GABA缺乏的证据，这与该疾病中的快感缺乏特别相关。
Abnormally low γ-aminobutyric acid (GABA) levels have been consistently reported in adults with major depressive disorder (MDD). Our group extended this finding to adolescents, and documented that GABA deficits were associated with anhedonia. Here we aimed to confirm our prior finding of decreased brain GABA in youth with depression and explore its associations with clinical variables. Forty-four psychotropic medication-free youth with MDD and 36 healthy control (HC) participants (12–21 years) were studied. Participants represent a combined sample of 39 newly recruited youth (MDD=24) and 41 youth from our previously reported study (MDD=20). GABA levels and the combined resonances of glutamate and glutamine (Glx) were measured in vivo in the anterior cingulate cortex using proton magnetic resonance spectroscopy. Youth with depression exhibited significantly lower GABA levels than HC in both the newly reported (P=0.003) and the combined (P=0.003) samples. When depressed participants were classified based on the presence of anhedonia, only the anhedonic MDD subgroup showed reduced GABA levels compared to HC (P=0.002). While there were no associations between any clinical measures and GABA or Glx levels in the new sample, GABA was negatively correlated with only anhedonia severity in the combined MDD group. Furthermore, in the combined sample, hierarchical regression models showed that anhedonia, but not depression severity, anxiety or suicidality, contributed significant variance in GABA levels. This report solidifies the evidence for a GABA deficit early in the course of MDD, which correlates specifically with anhedonia in the disorder.
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影响因子：
15.9
作者：
Der-Avakian A;Markou A
通讯作者：
Markou A
DOI：
10.1017/s1461145709990587
发表时间：
2010-05
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
Karolewicz B;Maciag D;O'Dwyer G;Stockmeier CA;Feyissa AM;Rajkowska G
通讯作者：
Rajkowska G
DOI：
10.1016/j.eurpsy.2015.08.009
发表时间：
2016-02
期刊：
European psychiatry : the journal of the Association of European Psychiatrists
影响因子：
--
作者：
Bradley KA;Mao X;Case JA;Kang G;Shungu DC;Gabbay V
通讯作者：
Gabbay V
DOI：
10.1097/01.chi.0000246065.93200.a1
发表时间：
2007-02-01
影响因子：
13.3
作者：
Baldwin, Jennifer S.;Dadds, Mark R.
通讯作者：
Dadds, Mark R.
影响因子：
4.6
作者：
Lewinsohn, PM;Rohde, P;Gotlib, IH
通讯作者：
Gotlib, IH