Cavitation properties of block copolymer stabilized phase-shift nanoemulsions used as drug carriers.

Cavitation properties of block copolymer stabilized phase-shift nanoemulsions used as drug carriers.
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DOI:
10.1016/j.ultrasmedbio.2009.11.009
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发表时间:
2010-03
影响因子:
2.9
通讯作者:
Nam, Kweon-Ho
Nam, Kweon-Ho
中科院分区:
医学3区
文献类型:
--
作者:
Rapoport, Natalya;Christensen, Douglas A.;Kennedy, Anne M.;Nam, Kweon-Ho

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研究了嵌段共聚物稳定的全氟戊烷纳米乳液的空化性能。通过两种可生物降解的两亲性嵌段共聚物,聚(环氧乙烷)-共-聚(L-丙交酯)(PEG-PLLA)和聚(环氧乙烷)-共-聚己内酯(PEG-PCL)的疏水嵌段的结构不同,稳定的纳米乳液。空化参数进行了测量,在液体乳液和凝胶作为一个功能的超声压力为非聚焦或聚焦1 MHz的超声。在液体基质和凝胶中,声液滴蒸发先于声空化的产生。对于聚焦超声,观察到稳定和惯性空化,而对于非聚焦超声,仅观察到稳定空化。
Cavitation properties of block copolymer stabilized perfluoropentane nanoemulsions have been investigated. The nanoemulsions were stabilized by two biodegradable amphiphilic block copolymers differing in the structure of the hydrophobic block, poly(ethylene oxide)-co-poly(L-lactide) (PEG-PLLA) and poly(ethylene oxide)-co-polycaprolactone (PEG-PCL). Cavitation parameters were measured in liquid emulsions and gels as a function of ultrasound pressure for unfocused or focused 1-MHz ultrasound. Acoustic droplet vaporization preceded generation of acoustic cavitation in liquid matrices and gels. Both stable and inertial cavitation was observed for focused ultrasound while only stable cavitation was observed for unfocused ultrasound.
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