Sex differences in the acute locomotor response to methamphetamine in BALB/c mice.
Sex differences in the acute locomotor response to methamphetamine in BALB/c mice.
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DOI：
10.1016/j.bbr.2017.03.030
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发表时间：
2017-06-01
影响因子：
2.7
通讯作者：
Kosten TA
中科院分区：
文献类型：
--
作者：
Ohia-Nwoko O;Haile CN;Kosten TA
女性比男性更频繁地使用甲基苯丙胺，更容易受到其负面心理影响的影响。啮齿动物模型一直是评估精神刺激剂的性别依赖效应的重要工具；然而，缺乏证据表明小鼠对甲基苯丙胺的行为反应存在性别差异。在本研究中，我们研究了急性甲基苯丙胺(1 mg/kg和4 mg/kg)诱导的雌性和雄性BALB/c小鼠的运动激活。我们还评估了基础运动活动是否与甲基苯丙胺诱导的运动反应有关。结果表明，雌性BALB/c小鼠表现出比雄性BALB/c小鼠更强的甲基苯丙胺诱导的运动活动，而雄性BALB/c小鼠的基础运动活动与甲基苯丙胺诱导的活动呈正相关，而雌性BALB/c小鼠的基础运动活动与甲基苯丙胺诱导的活动无关。这项研究首次显示了甲基苯丙胺对BALB/c小鼠的性别依赖性运动效应。我们的观察强调了在评估对甲基苯丙胺的行为反应时考虑性行为的重要性。
Women use methamphetamine more frequently than men and are more vulnerable to its negative psychological effects. Rodent models have been an essential tool for evaluating the sex-dependent effects of psychostimulants; however, evidence of sex differences in the behavioral responses to methamphetamine in mice is lacking. In the present study, we investigated acute methamphetamine-induced (1 mg/kg and 4 mg/kg) locomotor activation in female and male BALB/c mice. We also evaluated whether basal locomotor activity was associated with the methamphetamine-induced locomotor response. The results indicated that female BALB/c mice displayed enhanced methamphetamine-induced locomotor activity compared to males, while basal locomotor activity was positively correlated with methamphetamine-induced activity in males, but not females. This study is the first to show sex-dependent locomotor effects of methamphetamine in BALB/c mice. Our observations emphasize the importance of considering sex when assessing behavioral responses to methamphetamine.
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