Vitamin D supplementation during exercise training does not alter inflammatory biomarkers in overweight and obese subjects.
Vitamin D supplementation during exercise training does not alter inflammatory biomarkers in overweight and obese subjects.
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DOI：
10.1007/s00421-011-2279-3
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发表时间：
2012-08
影响因子：
3
通讯作者：
Teegarden, Dorothy
中科院分区：
文献类型：
--
作者：
Carrillo, Andres E.;Flynn, Michael G.;Pinkston, Catherine;Markofski, Melissa M.;Jiang, Yan;Donkin, Shawn S.;Teegarden, Dorothy
关键词：
本研究的目的是检查维生素D补充剂对参与渐进式阻力运动训练计划的超重和肥胖成年人的炎症生物标志物的影响。23名（26.1±4.7岁）超重和肥胖（BMI：31.3±3.2 kg·m−2）成人被随机分配到双盲维生素D补充剂（VitD，4000 IU/d，女性=5;男性=5）或安慰剂（PL，女性=7;男性=6）干预试验。两组均进行12周（3天/周）的渐进式抗阻运动训练（3组8次运动），重复次数最多为70 - 80%。在基线和12周干预后评估全血脂多糖（LPS）刺激的肿瘤坏死因子（TNF）α产生以及循环C反应蛋白（CRP）、TNFα、白细胞介素6（IL-6）和丙氨酸氨基转移酶（ALT）。未检测到组或时间对循环CRP、TNFα、IL-6和ALT的主要影响。正如预期的那样，当PL和VitD组合并时，基线时体脂百分比与CRP之间存在显著相关性（r=0.45，P=0.04），12周时血清25 OHD与CRP之间存在显著相关性（r=0.49，P=0.03）。干预12周后，PL组25 μg/ml LPS+多粘菌素B刺激的TNFα产生明显增加（P=0.04），两组未刺激的TNFα产生均明显减少（P<0.05）。在参与阻力训练干预的健康、超重和肥胖成年人中补充维生素D并没有增加运动引起的炎症生物标志物的变化。
The purpose of this study was to examine the effects of vitamin D supplementation on inflammatory biomarkers in overweight and obese adults participating in a progressive resistance exercise training program. Twenty-three (26.1±4.7 y) overweight and obese (BMI: 31.3±3.2 kg·m−2) adults were randomized into a double-blind vitamin D supplementation (VitD, 4000 IU/d, female=5; male=5) or placebo (PL, female=7; male=6) intervention trial. Both groups performed 12 wk (three d/wk) of progressive resistance exercise training (three sets of eight exercises) at 70 – 80% of one repetition maximum. Whole blood lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) α production as well as circulating C-reactive protein (CRP), TNFα, interleukin 6 (IL-6), and alanine aminotransferase (ALT) were assessed at baseline and after the 12 wk intervention. No main effects of group or time were detected for circulating CRP, TNFα, IL-6 and ALT. As expected, when PL and VitD groups were combined, there was a significant correlation between percent body fat and CRP at baseline (r=0.45, P=0.04), and between serum 25OHD and CRP at 12 weeks (r=0.49, P=0.03). The PL group had a significant increase in 25 μg/ml LPS+polymixin B-stimulated TNFα production (P=0.04), and both groups had a significant reduction in unstimulated TNFα production (P<0.05) after the 12 week intervention. Vitamin D supplementation in healthy, overweight and obese adults participating in a resistance training intervention did not augment exercise-induced changes in inflammatory biomarkers.
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影响因子：
11.1
作者：
Jorde, R.;Sneve, M.;Figenschau, Y.
通讯作者：
Figenschau, Y.
DOI：
10.1038/oby.2010.310
发表时间：
2011-06
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Fisher G;Hyatt TC;Hunter GR;Oster RA;Desmond RA;Gower BA
通讯作者：
Gower BA
DOI：
10.1249/mss.0b013e3181b11ab7
发表时间：
2010-02-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Phillips, Melody D.;Flynn, Michael G.;Timmerman, Kyle L.
通讯作者：
Timmerman, Kyle L.
影响因子：
3.5
作者：
Lechleitner, M;Herold, M;Dzien, A
通讯作者：
Dzien, A
影响因子：
5.5
作者：
Sitnick, Mitchell;Bodine, Sue C.;Rutledge, John C.
通讯作者：
Rutledge, John C.