Effect of diet with and without exercise training on markers of inflammation and fat distribution in overweight women.
Effect of diet with and without exercise training on markers of inflammation and fat distribution in overweight women.
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DOI：
10.1038/oby.2010.310
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Gower BA
中科院分区：
文献类型：
--
作者：
Fisher G;Hyatt TC;Hunter GR;Oster RA;Desmond RA;Gower BA
运动和减肥对肥胖者炎症标志物(MOI)的独立影响还没有明确的特征。这项研究的目的是：(I)确定运动和减肥对MOI的独立影响，以及(Ii)确定MOI的变化是否与脂肪分布的变化有关。受试者为126名健康的绝经前妇女，体重指数为27~30 kg/m2。他们被随机分为三组：单纯饮食组、饮食+有氧训练组或饮食+阻力训练组，直到体重指数达到25 kg/m2。用计算机断层扫描测量脂肪分布，用双能X线吸收测量仪测量身体成分。测定血清肿瘤坏死因子-α、可溶性肿瘤坏死因子受体1、可溶性肿瘤坏死因子受体2、C反应蛋白和白介素6水平。重复测量方差分析结果表明，时间对MOI有显著影响，即MOI随体重减轻而降低。混合模型分析结果显示，调整了腹内脂肪组织和总脂肪质量可以解释肿瘤坏死因子-α和肿瘤坏死因子-R1的下降，而只有总脂肪质量可以解释肿瘤坏死因子-R2、IL-6和C反应蛋白的下降。总而言之，体重减轻与MOI的减少有关。体重减轻的效果似乎是通过总脂肪质量或IAAT的变化来调节的。额外的锻炼并没有改变这种反应，这表明与锻炼相比，减肥对降低超重女性的MOI有更深远的影响。
The independent effects of exercise and weight loss on markers of inflammation (MOI) in obese individuals have not been clearly characterized. The objectives of this study were to: (i) identify the independent effects of exercise and weight loss on MOI and (ii) determine whether changes in MOI were associated with changes in fat distribution. Subjects were 126 healthy, premenopausal women, BMI 27–30 kg/m2. They were randomized to one of three groups: diet only, diet + aerobic-, or diet + resistance training until a BMI <25 kg/m2 was achieved. Fat distribution was measured with computed tomography, and body composition with dual-energy X-ray absorptiometry. Serum concentrations of tumor necrosis factor (TNF)-α, soluble TNF receptor 1 (sTNF-R1), soluble TNF receptor 2 (sTNF-R2), C-reactive protein (CRP), and interleukin (IL)-6 were assessed. Results of repeated-measures ANOVA indicated a significant effect of time on MOI, such that MOI decreased with weight loss. Results of mixed-model analysis indicated that adjusting for intra-abdominal adipose tissue (IAAT) and total fat mass explained the decreases in TNF-α and sTNF-R1, whereas only total fat mass explained the decreases in sTNF-R2, IL-6, and CRP. In conclusion, weight loss was associated with decreases in MOI. The effect of weight loss appeared to be mediated by changes in total fat mass or IAAT. Addition of exercise did not alter the response, suggesting that weight loss has a more profound impact for reducing MOI in overweight women than exercise.
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DOI：
10.1152/ajpendo.00574.2009
发表时间：
2010-04-01
影响因子：
5.1
作者：
Christiansen, Tore;Paulsen, Soren K.;Richelsen, Bjorn
通讯作者：
Richelsen, Bjorn
影响因子：
37.8
作者：
Pearson, TA;Mensah, GA;Vinicor, F
通讯作者：
Vinicor, F
影响因子：
--
作者：
Abramson, JL;Vaccarino, V
通讯作者：
Vaccarino, V
影响因子：
5.8
作者：
Bastard, JP;Jardel, C;Hainque, B
通讯作者：
Hainque, B
影响因子：
39.3
作者：
Lakka, TA;Lakka, HM;Bouchard, C
通讯作者：
Bouchard, C