PATTERN AND CHARACTERISTICS OF DRUSEN SUBTYPES IN CHINESE AND INDIAN POPULATIONS IN SINGAPORE
PATTERN AND CHARACTERISTICS OF DRUSEN SUBTYPES IN CHINESE AND INDIAN POPULATIONS IN SINGAPORE
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新加坡华人和印度人群中玻璃疣亚型的模式和特征
DOI：
10.1097/iae.0000000000003651
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Tan Anna C. S.
中科院分区：
文献类型：
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作者：
Takahashi Kengo;Song Youngseok;Cheong Kai Xiong;Fenner Beau J.;Teo Kelvin Yi Chong;Chee Miao Li;Li Hengtong;Tham Yih-Chung;Cheung Chui Ming Gemmy;Cheng Ching-Yu;Wong Tien Yin;Yanagi Yasuo;Tan Anna C. S.
目的：报告玻璃疣亚型在亚洲人群中的模式和特点，以及与脉络膜厚度的关系。方法：这是一项基于人群的队列研究的横断面分析。招募了1，336名年龄大于50岁的中国和印度参与者的2，353只眼睛，最佳矫正视力优于20/60，并且没有其他视网膜疾病。厚玻璃膜疣，网状假性玻璃膜疣，软，硬玻璃膜疣进行了分级的彩色眼底照片，光学相干断层扫描成像与自动分割产生和测量的脉络膜thickness.Results：九百五十五中国和381印度人被列入最后的分析。厚玻璃疣、软玻璃疣、硬玻璃疣和网状假玻璃疣的发生率分别为14.0%、3.7%、12.5%和0.2%。脉络膜厚度以玻璃膜厚疣最厚（298.3 μm; 95%置信区间：290.5-306.1），然后是硬眼（298.1 μm; 95%置信区间：290.6-305.5）和软性玻璃疣（293.7 μm; 95%置信区间：281.9-305.4），无玻璃疣眼最薄（284.6 μm; 95%置信区间：280.5-288.7）。系统协会的各种玻璃疣亚型也differed.Conclusion：模式，表征和脉络膜厚度的玻璃疣亚型，和他们的协会提供了深入了解亚洲表型谱的年龄相关性黄斑变性和潜在的发病机制。
Purpose:To report the pattern and characteristics of drusen subtypes in Asian populations and the association with choroidal thickness.Methods:This is the cross-sectional analysis of the population-based cohort study. Two thousand three hundred and fifty-three eyes of 1,336 Chinese and Indian participants aged older than 50 years, eyes with best-corrected visual acuity better than 20/60, and without other retinal diseases were recruited. Pachydrusen, reticular pseudodrusen, soft and hard drusen were graded on both color fundus photographs, and optical coherence tomography imaging with automated segmentation yielding and measurements of choroidal thickness.Results:Nine hundred and fifty-five Chinese and 381 Indians were included in the final analysis. The pattern of pachydrusen, soft drusen, hard drusen, and reticular pseudodrusen was 14.0%, 3.7%, 12.5%, and 0.2%, respectively. Mean choroidal thickness was the thickest in eyes with pachydrusen (298.3 μm; 95% confidence interval: 290.5–306.1), then eyes with hard (298.1 μm; 95% confidence interval: 290.6–305.5) and soft drusen (293.7 μm; 95% confidence interval: 281.9–305.4) and thinnest in eyes without drusen (284.6 μm; 95% confidence interval: 280.5–288.7). Systemic associations of the various drusen subtypes also differed.Conclusion:Patterns, characterization and choroidal thickness of drusen subtypes, and their associations provide insights into the Asian phenotypic spectrum of age-related macular degeneration and the underlying pathogenesis.
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日本人群中脉络膜厚度与中度 AMD 的关联
DOI：
--
发表时间：
2020
期刊：
影响因子：
--
作者：
佐々木 真理子;伊藤 賀一;山崎 知世;柳 靖雄;Gemmy Cheung;川上摂子; 木下 貴正;結城 賢弥;羽入田 明子;三村 将;澤田 典絵;津金 昌一郎;坪田 一男
通讯作者：
坪田 一男
影响因子：
4
作者：
Sabanayagam, Charumathi;Yip, Wanfen;Wong, Tien Yin
通讯作者：
Wong, Tien Yin
影响因子：
4.2
作者：
Manjunath, Varsha;Goren, Jordana;Fujimoto, James G.;Duker, Jay S.
通讯作者：
Duker, Jay S.
影响因子：
4.2
作者：
Boddu, Sucharita;Lee, Michele D.;Marsiglia, Marcela;Marmok, Michael;Freund, K. Bailey;Smith, R. Theodore
通讯作者：
Smith, R. Theodore
影响因子：
4.5
作者：
Matsumoto, Hidetaka;Hoshino, Junki;Akiyama, Hideo
通讯作者：
Akiyama, Hideo