Risk factors associated with reticular pseudodrusen versus large soft drusen.
Risk factors associated with reticular pseudodrusen versus large soft drusen.
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DOI：
10.1016/j.ajo.2014.01.023
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发表时间：
2014-05
影响因子：
4.2
通讯作者：
Smith, R. Theodore
中科院分区：
文献类型：
--
作者：
Boddu, Sucharita;Lee, Michele D.;Marsiglia, Marcela;Marmok, Michael;Freund, K. Bailey;Smith, R. Theodore
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PurposeTo investigate genetic, environmental, and systemic risk factors in prospectively identified subjects with the age-related macular degeneration (AMD) phenotypes of (1) reticular pseudodrusen without large soft drusen and (2) large soft drusen without reticular pseudodrusen.DesignProspective case-case comparison.MethodsIn a clinical practice setting, patients with AMD were sequentially screened using clinical examination and scanning laser ophthalmoscopy imaging to prospectively identify subjects (n = 73) with the phenotypes of (1) reticular pseudodrusen without large soft drusen (n = 30) or (2) large soft drusen without reticular pseudodrusen (n = 43). Subjects were genotyped for 2 alleles associated with AMD, age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH). A questionnaire was administered to collect history of smoking, hypertension, diabetes, and hyperlipidemia, as well as personal and family history of AMD.ResultsThe reticular pseudodrusen group was older (median age 87 vs 81 years,P= .04) and had more female subjects (83.3% vs 48.8%,P= .003), later ages of AMD onset (83 vs 70 years,P= .0005), and a greater frequency of hypertension (76.7% vs 55.8%,P= .08). No significant differences were found in the distribution of theARMS2risk allele (P= .4) between the reticular pseudodrusen (homozygous = 20.0%; heterozygous = 56.7%) and large soft drusen (homozygous = 19.0%; heterozygous = 42.9%) phenotypes, or in the distribution of theCHFrisk allele (P= .7) between the reticular pseudodrusen (homozygous = 26.7%; heterozygous = 56.7%) and large soft drusen (homozygous = 21.4%; heterozygous = 66.7%) phenotypes.ConclusionsThe reticular pseudodrusen phenotype was associated with increased age, later age of AMD onset, and female sex.
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影响因子：
8.3
作者：
Megnien, JL;Simon, A;Levenson, J
通讯作者：
Levenson, J
影响因子：
4.4
作者：
Hayreh, SS
通讯作者：
Hayreh, SS
影响因子：
--
作者：
Kassoff, A;Kassoff, J;Chew, EY
通讯作者：
Chew, EY
影响因子：
4.1
作者：
Metelitsina, TI;Grunwald, JE;Ying, GS
通讯作者：
Ying, GS
影响因子：
4.2
作者：
Klein, Ronald;Meuer, Stacy M.;Klein, Barbara E. K.
通讯作者：
Klein, Barbara E. K.