Matrix pre-coated MALDI MS targets for small molecule imaging in tissues.

Matrix pre-coated MALDI MS targets for small molecule imaging in tissues.
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DOI:
10.1007/s13361-010-0013-8
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发表时间:
2011-01
影响因子:
3.2
通讯作者:
Caprioli, Richard M.
Caprioli, Richard M.
中科院分区:
化学3区
文献类型:
--
作者:
Grove, Kerri J.;Frappier, Sara L.;Caprioli, Richard M.

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A new sample preparation method for MALDI tissue imaging has been developed for the analysis of low molecular weight compounds that employs matrix pre-coated MALDI targets. Tissue sections need only to be transferred onto the pre-coated target before analysis for fast and easy sample preparation. Pre-coated targets have a homogenous matrix coating with uniform crystals of approximately 1–2 μm and do not require solvents that may lead to analyte delocalization within a tissue section. We report here the use of matrix pre-coated targets for imaging of lipids, peptides, and pharmaceuticals in tissues.
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