Disruptive effects of posttraining perirhinal cortex lesions on conditioned fear: contributions of contextual cues.
Disruptive effects of posttraining perirhinal cortex lesions on conditioned fear: contributions of contextual cues.
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训练后鼻周皮层损伤对条件性恐惧的破坏性影响：情境线索的贡献。
DOI：
10.1037//0735-7044.109.4.613
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发表时间：
1995
影响因子：
1.9
通讯作者：
LeDoux,JE
中科院分区：
文献类型：
--
作者：
Corodimas,KP;LeDoux,JE
当听觉和视觉条件刺激出现在与条件反射环境不同的环境中时，恐惧条件反射后位于头侧鼻周皮层（rPRh）的损伤会干扰听觉和视觉条件刺激引起的条件恐惧反应的表达。本研究检验了当动物在条件反射环境中进行测试时，rPRh 的损伤是否具有类似的影响。雄性大鼠接受经典的恐惧调节（包括听觉条件刺激（CS）与足部电击配对）两天后，rPRh 中产生双侧电解损伤。五天后，在新环境中暴露于 CS 60 秒期间测量条件冻结行为，然后在条件环境中暴露 1 小时后测量条件冻结行为。有 3 个主要发现。首先，在新的环境中，rPRh 损伤的动物的冻结程度明显低于对照动物，从而证实了之前报道的发现。其次，rPRh 损伤的动物在条件反射环境中对 CS 的冻结程度也低于对照组，但在条件反射中对 CS 的冻结程度明显高于在新环境中，这表明新环境中的缺陷至少部分是由于缺乏上下文线索造成的。第三，患有 rPRh 损伤的动物在条件反射环境中的冻结程度明显低于对照组。后一项发现表明，rPRh 损伤会干扰情境处理，并且如果受损动物能够完全处理情境线索，则在调节情境中的表现可能会得到更大的改善。总之，这些结果支持了这样的假设：鼻周皮层是记忆过程的重要大脑区域，并且可能特别参与使用上下文线索作为检索辅助工具。
Lesions placed in the rostral perirhinal cortex (rPRh) after fear conditioning interfere with the expression of conditioned fear responses elicited by auditory and visual conditioned stimuli when these stimuli are presented in a context that differs from the conditioning context. The present study examined whether lesions of the rPRh have similar effects when animals are tested in the conditioning context. Two days after male rats received classical fear conditioning, involving the pairing of an auditory conditioned stimulus (CS) with footshock, bilateral electrolytic lesions were produced in the rPRh. Five days later conditioned freezing behavior was measured during a 60-s exposure to the CS in a novel context and then 1 hr later in the conditioning context. There were 3 major findings. First, rPRh-lesioned animals froze significantly less than controls to the CS in the novel context, thus confirming previously reported findings. Second, rPRh-lesioned animals also froze less than controls to the CS in the conditioning context, but froze significantly more to the CS in the conditioning than in the novel context, suggesting that at least part of the deficit in the novel context is due to the absence of contextual cues. Third, animals with rPRh lesions froze significantly less than controls to the conditioning context itself. This latter finding suggests that rPRh lesions interfere with contextual processing and that the improvement of performance in the conditioning context might have been even greater had lesioned animals been able to fully process contextual cues. Together, the results support the hypothesis that the perirhinal cortex is an important brain region for memory processes and may be especially involved in the use of contextual cues as retrieval aids.
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海马体、环境和调节。
影响因子：
1.9
作者：
S. Penick;P. Solomon
通讯作者：
P. Solomon
环境和条件：空间的场所
DOI：
10.3758/bf03332853
发表时间：
1980
期刊：
Psychobiology
影响因子：
--
作者：
L. Nadel;J. Willner
通讯作者：
J. Willner
DOI：
10.1016/s0091-6773(74)92231-7
发表时间：
1974-01-01
期刊：
BEHAVIORAL BIOLOGY
影响因子：
--
作者：
HIRSH, R
通讯作者：
HIRSH, R
影响因子：
1.9
作者：
BORDI, F;LEDOUX, J;PAVLIDES, C
通讯作者：
PAVLIDES, C
DOI：
10.3758/bf03199629
发表时间：
1980-01-01
期刊：
ANIMAL LEARNING & BEHAVIOR
影响因子：
--
作者：
BOUTON, ME;BOLLES, RC
通讯作者：
BOLLES, RC