Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminants.
Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminants.
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DOI：
10.1289/ehp.0800219
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发表时间：
2009-06
影响因子：
10.4
通讯作者：
Ayotte P
中科院分区：
文献类型：
--
作者：
Dallaire R;Muckle G;Dewailly E;Jacobson SW;Jacobson JL;Sandanger TM;Sandau CD;Ayotte P
越来越多的研究表明，几种普遍存在的环境污染物具有干扰甲状腺激素的能力。产前接触其中一些物质，例如多氯联苯 (PCB)，也与婴儿神经发育的不良影响有关。在这项研究中，我们研究了来自努纳维克的因纽特孕妇及其出生后第一年内的婴儿，接触潜在的甲状腺激素干扰毒物与甲状腺激素状态之间的关系。我们测量了分娩时母体血浆中的甲状腺激素参数 [促甲状腺激素 (TSH)、游离甲状腺素 (fT4)、总三碘甲状腺原氨酸 (T3)、甲状腺素结合球蛋白 (TBG)] 和几种污染物 [PCB-153、多氯联苯羟基化代谢物 (HO-PCBs)、五氯苯酚 (PCP) 和六氯苯 (HCB)] 的浓度 (n = 120)，脐带血浆 (n = 95) 和产后 7 个月的婴儿血浆 (n = 130)。在孕妇中，我们发现 HO-PCB 与 T3 浓度呈正相关（β = 0.57，p = 0.02）。在脐带血中，PCB-153 浓度与 TBG 水平呈负相关（β = -0.26，p = 0.01）。在子样本分析中，还发现母亲 PCP 水平与新生儿脐带 fT4 浓度之间存在负相关关系（β = -0.59，p = 0.02）。 7 个月大时，未观察到污染物与甲状腺激素之间存在关联。总体而言，几乎没有证据表明本研究中分析的环境污染物会影响因纽特母亲及其婴儿的甲状腺激素状态。 PCP 可能降低新生儿甲状腺素水平的可能性需要进一步研究。
An increasing number of studies have shown that several ubiquitous environmental contaminants possess thyroid hormone–disrupting capacities. Prenatal exposure to some of them, such as polychlorinated biphenyls (PCBs), has also been associated with adverse neurodevelopmental effects in infants. In this study we examined the relationship between exposure to potential thyroid hormone–disrupting toxicants and thyroid hormone status in pregnant Inuit women from Nunavik and their infants within the first year of life. We measured thyroid hormone parameters [thyroid stimulating hormone (TSH), free thyroxine (fT4), total triiodothyronine (T3), thyroxine-binding globulin (TBG)] and concentrations of several contaminants [PCB-153, hydroxylated metabolites of PCBs (HO-PCBs), pentachlorophenol (PCP) and hexachlorobenzene (HCB)] in maternal plasma at delivery (n = 120), in umbilical cord plasma (n = 95), and in infant plasma at 7 months postpartum (n = 130). In pregnant women, we found a positive association between HO-PCBs and T3 concentrations (β = 0.57, p = 0.02). In umbilical cord blood, PCB-153 concentrations were negatively associated with TBG levels (β = −0.26, p = 0.01). In a subsample analysis, a negative relationship was also found between maternal PCP levels and cord fT4 concentrations in neonates (β = −0.59, p = 0.02). No association was observed between contaminants and thyroid hormones at 7 months of age. Overall, there is little evidence that the environmental contaminants analyzed in this study affect thyroid hormone status in Inuit mothers and their infants. The possibility that PCP may decrease thyroxine levels in neonates requires further investigation.
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影响因子：
3.8
作者：
Richardson, Vicki M.;Staskal, Daniele F.;Bimbaum, Linda S.
通讯作者：
Bimbaum, Linda S.
影响因子：
10.4
作者：
Maervoet J;Vermeir G;Covaci A;Van Larebeke N;Koppen G;Schoeters G;Nelen V;Baeyens W;Schepens P;Viaene MK
通讯作者：
Viaene MK
DOI：
10.1016/s0169-328x(00)00190-x
发表时间：
2000-10-20
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Dowling, ALS;Zoeller, RT
通讯作者：
Zoeller, RT
影响因子：
3.2
作者：
Pop, VJ;Brouwers, EP;de Vijlder, JJ
通讯作者：
de Vijlder, JJ
影响因子：
4.9
作者：
Ribas-Fitó, N;Sala, M;Sunyer, J
通讯作者：
Sunyer, J