Association of thyroid hormone concentrations with levels of organochlorine compounds in cord blood of neonates.
Association of thyroid hormone concentrations with levels of organochlorine compounds in cord blood of neonates.
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DOI：
10.1289/ehp.10486
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发表时间：
2007-12
影响因子：
10.4
通讯作者：
Viaene MK
中科院分区：
文献类型：
--
作者：
Maervoet J;Vermeir G;Covaci A;Van Larebeke N;Koppen G;Schoeters G;Nelen V;Baeyens W;Schepens P;Viaene MK
甲状腺激素是大脑发育的重要调节因素。在发育的关键时期，即使是短暂的甲状腺激素供应障碍也可能导致严重的神经损伤。动物实验表明，某些环境污染物，包括重金属和有机氯化合物，如多氯联苯和二恶英，可以干扰甲状腺激素的动态平衡。然而，这些污染物是否会影响人类甲状腺激素的循环水平尚不清楚，因为现有研究的结果并不一致。本研究的目的是研究环境污染物浓度与人脐血中甲状腺激素水平之间的可能关系。我们测定了198名新生儿脐血中环境污染物[包括选定的多氯联苯、二恶英类化合物、六氯苯、二氯二苯基二氯乙烯、镉、铅]和甲状腺激素的浓度。观察到有机氯化合物浓度与游离三碘甲腺原氨酸(FT3)和游离甲状腺激素(FT4)水平呈显著负相关，但不包括促甲状腺激素。我们发现重金属浓度和甲状腺激素水平之间没有关联。我们的结果表明，环境化学物质可能会影响人类新生儿的甲状腺系统。尽管与有机氯化合物相关的FT3和FT4水平的差异在正常范围内，但鉴于甲状腺激素在大脑发育中的重要性，所观察到的干扰仍可能对个别儿童的神经发育产生不利影响。
Thyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead to profound neurologic impairment. Animal experiments have shown that certain environmental pollutants, including heavy metals and organochlorine compounds such as polychlorinated biphenyls (PCBs) and dioxins, can interfere with thyroid hormone homeostasis. Whether these contaminants can affect circulating levels of thyroid hormones in humans is unclear, however, because the results of available studies are inconsistent. The aim of the present study is to examine the possible relationships between concentrations of environmental pollutants and thyroid hormone levels in human umbilical cord blood. We measured concentrations of environmental pollutants [including selected PCBs, dioxin-like compounds, hexachlorobenzene, p,p′-DDE (dichlorodiphenyldichloroethylene), cadmium, lead] and thyroid hormones in the cord blood of 198 neonates. A statistically significant inverse relationship between concentrations of organochlorine compounds and levels of both free triiodothyronine (fT3) and free thyroxine (fT4), but not thyroid-stimulating hormone, was observed. We found no association between concentrations of heavy metals and thyroid hormone levels. Our results suggest that environmental chemicals may affect the thyroid system of human neonates. Although the differences in fT3 and fT4 levels associated with the organochlorine compounds were within the normal range, the observed interferences may still have detrimental effects on the neurologic development of the individual children, given the importance of thyroid hormones in brain development.
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影响因子：
10.4
作者：
Crofton KM;Craft ES;Hedge JM;Gennings C;Simmons JE;Carchman RA;Carter WH Jr;DeVito MJ
通讯作者：
DeVito MJ
DOI：
10.1016/j.beem.2004.03.012
发表时间：
2004-06-01
影响因子：
7.4
作者：
de Escobar, GM;Obregón, MJ;del Rey, FE
通讯作者：
del Rey, FE
影响因子：
2.5
作者：
HUISMAN, M;KOOPMANESSEBOOM, C;BOERSMA, ER
通讯作者：
BOERSMA, ER
影响因子：
6.6
作者：
Bernal, J;Guadaño-Ferraz, A;Morte, B
通讯作者：
Morte, B
影响因子：
6.6
作者：
Hagmar, L
通讯作者：
Hagmar, L