Dimensionality reduction for large-scale neural recordings.
Dimensionality reduction for large-scale neural recordings.
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DOI:
10.1038/nn.3776
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发表时间:
2014-11
影响因子:
25
通讯作者:
Yu, Byron M.
中科院分区:
文献类型:
--
作者:
Cunningham, John P.;Yu, Byron M.
Most sensory, cognitive and motor functions depend on the interactions of many neurons. In recent years, there has been rapid development and increasing use of technologies for recording from large numbers of neurons, either sequentially or simultaneously. A key question is what scientific insight can be gained by studying a population of recorded neurons beyond studying each neuron individually. Here, we examine three important motivations for population studies: single-trial hypotheses requiring statistical power, hypotheses of population response structure and exploratory analyses of large data sets. Many recent studies have adopted dimensionality reduction to analyze these populations and to find features that are not apparent at the level of individual neurons. We describe the dimensionality reduction methods commonly applied to population activity and offer practical advice about selecting methods and interpreting their outputs. This review is intended for experimental and computational researchers who seek to understand the role dimensionality reduction has had and can have in systems neuroscience, and who seek to apply these methods to their own data.
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影响因子:
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作者:
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通讯作者:
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DOI:
10.1073/pnas.92.19.8616
发表时间:
1995-09-12
影响因子:
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DOI:
10.1126/science.1195870
发表时间:
2011-01-07
期刊:
Science (New York, N.Y.)
影响因子:
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作者:
Berkes P;Orbán G;Lengyel M;Fiser J
通讯作者:
Fiser J