Relationship between sedentary behavior and endothelial dysfunction in a cross-sectional study in China.
Relationship between sedentary behavior and endothelial dysfunction in a cross-sectional study in China.
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DOI：
10.3389/fcvm.2023.1148353
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发表时间：
2023
影响因子：
3.6
通讯作者：
Li, Ying
中科院分区：
文献类型：
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作者：
Yang, Ping-ting;Yang, Sai-qi;He, Yong-mei;Wang, Jian-gang;Qin, Yue-xiang;Wang, Ya-qin;Li, Ying
久坐行为是多种疾病的危险因素，以往的研究大多报道了急性久坐行为对血管内皮功能的影响。缺乏大样本人群中久坐不动的生活习惯与血管功能之间关系的数据。因此，本研究的目的是评估自我报告的久坐行为和外周血管功能之间的相关性，从现实世界的数据检查人群。我们在2017年至2021年期间从位于中国北方和南方的两个综合性三级医院的健康管理中心招募了13，220名参与者。所有参与者都接受了问卷调查和肱动脉血流介导的扩张（FMD）测量。总共有3，205名FMD ≤ 5.0%的参与者被确定患有内皮功能障碍。在包括久坐行为等生活习惯和心血管危险因素的多变量回归模型中，以休闲久坐时间<2 h/d为参考，血管内皮功能障碍的风险随时间逐渐增加：2-4 h/d（OR = 1.182，95%CI：1.058-1.321，P = 0.003）、4-6 h/d（OR = 1.248，95%CI：1.100-1.414，P = 0.001）和>6 h/d（OR = 1.618，95%CI：1.403-1.866，P < 0.001）。 休闲久坐时间越长，血管内皮功能障碍的患病率越高。这些结果表明，休闲久坐行为是中国体检人群血管内皮功能障碍发生的危险因素。
Sedentary behavior is a risk factor for several diseases, and previous studies have mostly reported the effects of acute sedentary behavior on vascular endothelial function. Data on the relationship between sedentary lifestyle habits and vascular function in large sample populations are lacking. Therefore, the aim of this study was to assess the correlation between self-reported sedentary behavior and peripheral vascular function in a check-up population from real-world data. We recruited 13,220 participants from two health management centers of general tertiary hospitals located in northern and southern China between 2017 and 2021. All participants had undergone both questionnaires and brachial artery flow-mediated dilation (FMD) measurements. In total, 3,205 participants with FMD ≤ 5.0% were identified to have endothelial dysfunction. In a multivariable regression model including lifestyle habits such as sedentary behavior and cardiovascular risk factors, taking leisure sedentary time <2 h/day as a reference, the risk of vascular endothelial dysfunction gradually increased with time: 2–4 h/day (OR = 1.182, 95% CI: 1.058–1.321, P = 0.003), 4–6 h/day (OR = 1.248, 95% CI: 1.100–1.414, P = 0.001) and >6 h/day (OR = 1.618, 95% CI: 1.403–1.866, P < 0.001). Longer leisure sedentary time is associated with a higher prevalence of vascular endothelial dysfunction. These findings suggest that leisure sedentary behavior is a risk factor for the occurrence of vascular endothelial dysfunction in the Chinese check-up population.
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影响因子：
2.8
作者：
Shechter, Michael;Shechter, Alon;Hiersch, Liran
通讯作者：
Hiersch, Liran
DOI：
10.3390/ijerph18179275
发表时间：
2021-09-02
影响因子：
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作者：
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通讯作者：
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影响因子：
4.4
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Tang J;Liu K;Eshak ES;Cui R;Sakaniwa R;Imano H;Dong JY;Iso H
通讯作者：
Iso H
影响因子：
4.8
作者：
Jambrik, Z;Venneri, L;Picano, E
通讯作者：
Picano, E
影响因子：
15.1
作者：
通讯作者：
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