Traumatic microbleeds persist for up to five years following traumatic brain injury despite resolution of other acute findings on MRI.
Traumatic microbleeds persist for up to five years following traumatic brain injury despite resolution of other acute findings on MRI.
复制标题
DOI：
10.1080/02699052.2020.1725835
复制
发表时间：
2020-05-11
期刊：
影响因子：
1.9
通讯作者：
Chan L
中科院分区：
文献类型：
--
作者：
Rizk T;Turtzo LC;Cota M;Van Der Merwe AJ;Latour L;Whiting MD;Chan L
本研究的主要目的是跟踪创伤性脑损伤（TBI）后长达5年的创伤性微出血（TMB）的发生率和进展。30例轻度、中度或重度TBI患者在受伤后48小时内接受了初次MRI检查，并继续进行长达5年的纵向研究。在5年期间评估MRI结果的发生率和进展。除了TMB，我们还发现了其他影像学表现，包括弥散加权成像（DWI）病变、轴外和脑室内出血、血肿、创伤性脑膜增强（TME）、液体衰减反转恢复（FLAIR）高信号和脑软化。60%的患者在初次就诊时观察到TMB。在一年的随访中，TMB比其他神经影像学结果更持久，83%的MRI可见。在受伤后2-5年接受系列MRI的患者中，在所有随访扫描中均可见急性TMB。相比之下，大多数TBI的其他成像标志物在损伤后一年内已经解决或演变成模糊的成像异常。这些研究结果表明，TMB可能作为一个独特的持久性指标TBI和加强急性损伤后成像的重要性，准确表征持久的成像结果。
The primary objective of this study was to track the incidence and progression of traumatic microbleeds (TMBs) for up to five years following traumatic brain injury (TBI). Thirty patients with mild, moderate, or severe TBI received initial MRI within 48 h of injury and continued in a longitudinal study for up to five years. The incidence and progression of MRI findings was assessed across the five year period. In addition to TMBs, we noted the presence of other imaging findings including diffusion weighted imaging (DWI) lesions, extra-axial and intraventricular hemorrhage, hematoma, traumatic meningeal enhancement (TME), fluid-attenuated inversion recovery (FLAIR) hyperintensities, and encephalomalacia. TMBs were observed in 60% of patients at initial presentation. At one-year follow-up, TMBs were more persistent than other neuroimaging findings, with 83% remaining visible on MRI. In patients receiving serial MRI 2–5 years post-injury, acute TMBs were visible on all follow-up scans. In contrast, most other imaging markers of TBI had either resolved or evolved into ambiguous abnormalities on imaging by one year post-injury. These findings suggest that TMBs may serve as a uniquely persistent indicator of TBI and reinforce the importance of acute post-injury imaging for accurate characterization of persistent imaging findings.
登录
查看更多内容
DOI：
10.1093/brain/awx350
发表时间：
2018-02-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Tagge CA;Fisher AM;Minaeva OV;Gaudreau-Balderrama A;Moncaster JA;Zhang XL;Wojnarowicz MW;Casey N;Lu H;Kokiko-Cochran ON;Saman S;Ericsson M;Onos KD;Veksler R;Senatorov VV Jr;Kondo A;Zhou XZ;Miry O;Vose LR;Gopaul KR;Upreti C;Nowinski CJ;Cantu RC;Alvarez VE;Hildebrandt AM;Franz ES;Konrad J;Hamilton JA;Hua N;Tripodis Y;Anderson AT;Howell GR;Kaufer D;Hall GF;Lu KP;Ransohoff RM;Cleveland RO;Kowall NW;Stein TD;Lamb BT;Huber BR;Moss WC;Friedman A;Stanton PK;McKee AC;Goldstein LE
通讯作者：
Goldstein LE
影响因子：
4
作者：
Brundel, Manon;Heringa, Sophie M.;Biessels, Geert Jan
通讯作者：
Biessels, Geert Jan
影响因子：
3.5
作者：
Izzy, Saef;Mazwi, Nicole L.;Edlow, Brian L.
通讯作者：
Edlow, Brian L.
影响因子：
14.5
作者：
Griffin, Allison D.;Turtzo, L. Christine;Latour, Lawrence L.
通讯作者：
Latour, Lawrence L.
影响因子：
6.1
作者：
Liu J;Kou Z;Tian Y
通讯作者：
Tian Y