Bridging a mechanistic gap from diet to synapses.
Bridging a mechanistic gap from diet to synapses.
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DOI：
10.1073/pnas.2309992120
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发表时间：
2023-08-15
影响因子：
11.1
通讯作者：
Layé S
中科院分区：
文献类型：
--
作者：
Benson DL;Layé S
母乳对婴儿营养至关重要，是营养素和生物活性成分的复杂混合物（1）。它满足了婴儿的高能量需求，通过蛋白质，脂肪和乳糖支持出生后的生长。虽然母乳的成分通常是一致的，但母乳会调整常量营养素水平，以满足成长中儿童的需求。它还提供受母亲饮食影响的微量营养素。除营养外，人乳还含有促进婴儿存活和发育的非营养性生物活性因子。一个例子是瘦素，它有助于代谢程序和防止晚年肥胖。初乳和成熟的牛奶具有支持肠道功能和保护免受感染的生物活性分子（1）。令人着迷的是，母乳具有在前1,000天内促进大脑快速发育的最佳成分，引发显着的认知进步并规划终身认知轨迹。虽然母乳喂养对婴儿认知结构的一些有益影响被归因于多不饱和脂肪酸（PUFA），人乳低聚糖和唾液酸等关键营养素，但其他营养因素对大脑的诱人影响有待进一步探索。
Human milk, vital for infant nutrition, is a complex blend of nutrients and bioactive components (1). It meets the high energy demands of babies, supporting postnatal growth through proteins, fats, and lactose. While its composition is generally consistent, human milk adjusts macronutrient levels to meet a growing child’s needs. It also provides micronutrients influenced by maternal diet. Besides nutrition, human milk contains nonnutritive bioactive factors promoting infant survival and development. An example is leptin, which aids metabolic programming and protects against later-life obesity. Colostrum and mature milk have bioactive molecules supporting gut function and protecting against infections (1).It is fascinating that human milk has the optimal composition to fuel rapid brain development in the first 1,000 days, igniting remarkable cognitive progress and programming a lifelong cognitive trajectory. While some beneficial effects of breastfeeding on the construction of cognition in babies have been attributed to crucial nutrients like polyunsaturated fatty acids (PUFAs), human milk oligosaccharides, and sialic acid, the tantalizing impact of other nutritional factors on the brain awaits further exploration.
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影响因子：
3.7
作者：
Carbone, Beatrice E.;Abouleish, Malik;Biederer, Thomas
通讯作者：
Biederer, Thomas
影响因子：
2.6
作者：
Ballard, Olivia;Morrow, Ardythe L.
通讯作者：
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影响因子：
16.6
作者：
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通讯作者：
Layé S
影响因子：
7.1
作者：
CLEMENTS, RS;DARNELL, B
通讯作者：
DARNELL, B
影响因子：
3.9
作者：
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通讯作者：
Paisan-Ruiz, Coro