Operationalization of Intrinsic Capacity in Older People and Its Association With Subsequent Disability, Hospital Admission and Mortality: Results From The English Longitudinal Study of Ageing.
Operationalization of Intrinsic Capacity in Older People and Its Association With Subsequent Disability, Hospital Admission and Mortality: Results From The English Longitudinal Study of Ageing.
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DOI：
10.1093/gerona/glac250
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发表时间：
2023-03-30
影响因子：
5.1
通讯作者：
Zaninotto, Paola
中科院分区：
文献类型：
--
作者：
Campbell, Charlotte L.;Cadar, Dorina;McMunn, Anne;Zaninotto, Paola
内禀容量是健康老龄化领域的一个新概念，有许多可操作的定义。在这项研究中，我们使用项目反应理论在英语老龄化纵向研究(ELSA)中对IC进行操作，并使用随后的功能能力、死亡率和入院时间来测试该量表的预测价值。在基线(2004，第2波)时，使用14个二分指标来测量IC：单词回忆、时间定向、平衡、椅子上升、行走速度、上活动、下活动、视力、听力、握力、身体质量指数、腰围、抑郁症状和生活满意度。采用双参数项目反应理论模型，在基线条件下编制IC量表。用≥-1日常生活活动能力(ADL)和≥-1日常生活能力量表(IADL)在基线后4年和8年的困难来预测随后的困难。在14年的随访中，分别采用竞争风险和COX回归来检验入院和死亡率的预测。对4545名平均年龄为70.8岁的人进行了IC评分(标准差[SD]7.93)。在调整社会人口学和健康相关的协变量后，更好的基线IC评分与ADL和IADLS后续困难的风险降低、住院(次分布风险比[SHR]=0.99，95%可信区间[CI]0.98-0.99)和死亡率(风险比[HR]=0.98，95%CI 0.98-0.99)相关。这些结果表明，IC评分可作为老年人未来不良后果风险的衡量标准，可能高于其他社会人口学和健康相关因素所显示的结果。
Intrinsic capacity (IC) is a new concept in the healthy aging field and has many operationalized definitions. In this study, we operationalized IC using item response theory in the English Longitudinal Study of Ageing (ELSA) and tested the predictive value of the scale using a subsequent functional ability, mortality, and hospital admission. IC was measured at baseline (2004, Wave 2) using 14 dichotomous indicators: word recall, orientation in time, balance, chair rises, walking speed, upper mobility, lower mobility, eyesight, hearing, grip strength, body mass index, waist circumference, depressive symptoms, and life satisfaction. A 2-parameter item response theory model was used to generate a scale of IC at baseline. Logistic regression was used for the prediction of subsequent difficulties, measured by difficulties with ≥1 activities of daily living (ADLs) and ≥1 instrumental activities of daily living (IADLs) at 4 and 8 years after baseline. Competing risk and Cox regressions were employed to test the prediction of hospital admission and mortality, respectively, over a 14-year follow-up. IC scores were generated for 4 545 individuals aged on average 70.8 years (standard deviation [SD] 7.93). Better baseline IC scores were associated with reduced risk of subsequent difficulties with ADLs and IADLs, hospital admission (subdistribution hazard ratios [SHR] = 0.99, 95% confidence interval [CI] 0.98–0.99), and mortality (hazard ratios [HR] = 0.98, 95% CI 0.98–0.99), when adjusted for sociodemographic and health-related covariates. These results suggest the utility of this IC score as a measure of risk for future adverse outcomes in older people, potentially above that indicated by other sociodemographic and health-related factors.
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影响因子：
5.8
作者：
Gutierrez-Robledo, L. M.;Garcia-Chanes, R. E.;Perez-Zepeda, M. U.
通讯作者：
Perez-Zepeda, M. U.
影响因子：
3.9
作者：
Guyonnet, S.;Rolland, Y.;Vellas, B.
通讯作者：
Vellas, B.
影响因子：
4.9
作者：
Salinas-Rodriguez, Aaron;Gonzalez-Bautista, Emmanuel;Manrique-Espinoza, Betty
通讯作者：
Manrique-Espinoza, Betty
影响因子：
3.9
作者：
Angioni D;Nicolay C;Vandergheynst F;Baré R;Cesari M;De Breucker S
通讯作者：
De Breucker S
影响因子：
7.7
作者：
Sanchez-Niubo A;Forero CG;Wu YT;Giné-Vázquez I;Prina M;De La Fuente J;Daskalopoulou C;Critselis E;De La Torre-Luque A;Panagiotakos D;Arndt H;Ayuso-Mateos JL;Bayes-Marin I;Bickenbach J;Bobak M;Caballero FF;Chatterji S;Egea-Cortés L;García-Esquinas E;Leonardi M;Koskinen S;Koupil I;Mellor-Marsá B;Olaya B;Pająk A;Prince M;Raggi A;Rodríguez-Artalejo F;Sanderson W;Scherbov S;Tamosiunas A;Tobias-Adamczyk B;Tyrovolas S;Haro JM;ATHLOS Consortium
通讯作者：
ATHLOS Consortium