Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease.
Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease.
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DOI：
10.1186/s12929-017-0346-8
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发表时间：
2017-07-08
影响因子：
11
通讯作者：
Matsakas A
中科院分区：
文献类型：
--
作者：
Sfyri P;Matsakas A
动脉粥样硬化是一种慢性炎症过程，在存在高脂血症的情况下，在大型心血管系统中促进了动脉粥样硬化的斑块，它也影响了周围动脉的主要影响。 ，肝脏和肾脏的目的是批判性地讨论和吸收有关周围动脉粥样硬化的影响，其对骨骼肌肉稳态的影响表明，累积的数据表明了骨骼肌肉中的骨骼肌肉中的表现。 increased i)-oxidative stress, ii)-inflammation, iii)-mitochondrial deficiencies, iv)-altered myofibre morphology and fibrosis, v)-chronic ischemia followed by impaired oxygen supply, vi)-reduced capillary density, vii)-proteolysis and viii） - 凋亡。 ：a） - 来自公认的动脉粥样硬化模型的大量证据；心血管疾病中的活性氧的重要来源是纳德氧化物的家族，导致了几种病理学，靶向骨骼肌中的nadph氧化物的策略，试图减轻细胞氧化应激，从而更好地理解周围动脉粥样硬化与骨骼肌病理生理学之间的十字路口。
Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system. It also affects peripheral arteries with major implications for a number of other non-vascular tissues such as the skeletal muscle, the liver and the kidney. The aim of this review is to critically discuss and assimilate current knowledge on the impact of peripheral atherosclerosis and its implications on skeletal muscle homeostasis. Accumulating data suggests that manifestations of peripheral atherosclerosis in skeletal muscle originates in a combination of increased i)-oxidative stress, ii)-inflammation, iii)-mitochondrial deficits, iv)-altered myofibre morphology and fibrosis, v)-chronic ischemia followed by impaired oxygen supply, vi)-reduced capillary density, vii)- proteolysis and viii)-apoptosis. These structural, biochemical and pathophysiological alterations impact on skeletal muscle metabolic and physiologic homeostasis and its capacity to generate force, which further affects the individual’s quality of life. Particular emphasis is given on two major areas representing basic and applied science respectively: a)-the abundant evidence from a well-recognised atherogenic model; the Apolipoprotein E deficient mouse and the role of a western-type diet and b)-on skeletal myopathy and oxidative stress-induced myofibre damage from human studies on peripheral arterial disease. A significant source of reactive oxygen species production and oxidative stress in cardiovascular disease is the family of NADPH oxidases that contribute to several pathologies. Finally, strategies targeting NADPH oxidases in skeletal muscle in an attempt to attenuate cellular oxidative stress are highlighted, providing a better understanding of the crossroads between peripheral atherosclerosis and skeletal muscle pathophysiology.
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影响因子：
29
作者：
Baker RG;Hayden MS;Ghosh S
通讯作者：
Ghosh S
血管细胞对成肌干细胞行为的调控 卫星细胞、内皮周围细胞和内皮细胞的 "三人行"
影响因子：
4.3
作者：
Abou-Khalil, Rana;Mounier, Remi;Chazaud, Benedicte
通讯作者：
Chazaud, Benedicte
影响因子：
8.2
作者：
Bartelt, A.;Orlando, P.;Di Marzo, V.
通讯作者：
Di Marzo, V.
影响因子：
15.9
作者：
Barry-Lane, PA;Patterson, C;Runge, MS
通讯作者：
Runge, MS
影响因子：
3.3
作者：
Arai, Yoshio;Fujita, Masatoshi;Komeda, Masashi
通讯作者：
Komeda, Masashi