Nogo receptor 1 limits tactile task performance independent of basal anatomical plasticity.
Nogo receptor 1 limits tactile task performance independent of basal anatomical plasticity.
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DOI：
10.1371/journal.pone.0112678
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
McGee AW
中科院分区：
文献类型：
--
作者：
Park JI;Frantz MG;Kast RJ;Chapman KS;Dorton HM;Stephany CÉ;Arnett MT;Herman DH;McGee AW
我们对控制经验如何改善神经回路和改变突触结构可塑性的基因知之甚少。nogo-66受体1基因（ngr 1）是一个可能限制成人大脑皮层学习速度和基础解剖可塑性的候选基因。为了研究ngr 1是否限制了学习速度，我们测试了ngr 1基因缺失的成年小鼠的触觉学习任务。NGR 1突变体显示出更大的整体性能，尽管在缺口交叉试验（一种须依赖性学习范式）上的改善率正常。为了确定ngr 1是否限制相关感觉皮层的基础解剖可塑性，我们通过颅窗用双光子慢性体内成像反复成像了两周的体感桶皮层中的组成性和条件性成年ngr 1突变小鼠的树突棘和轴突静脉曲张。无论是恒定或急性缺失的ngr 1影响营业额或稳定的树突棘或轴突终扣。在间隙交叉任务中表现的改善并不归因于更好的运动协调，因为ngr 1突变小鼠在整体表现上有轻微缺陷，在旋转杆（一种运动任务）上的学习率正常。缺乏ngr 1的小鼠也表现出与音调相关的恐惧条件反射的正常诱导，但加速了恐惧消退和受损的巩固。因此，ngr 1改变触觉和运动任务的表现，但似乎并不限制触觉或运动学习的速度，也不确定在感觉皮层突触营业额的低设定点。
The genes that govern how experience refines neural circuitry and alters synaptic structural plasticity are poorly understood. The nogo-66 receptor 1 gene (ngr1) is one candidate that may restrict the rate of learning as well as basal anatomical plasticity in adult cerebral cortex. To investigate if ngr1 limits the rate of learning we tested adult ngr1 null mice on a tactile learning task. Ngr1 mutants display greater overall performance despite a normal rate of improvement on the gap-cross assay, a whisker-dependent learning paradigm. To determine if ngr1 restricts basal anatomical plasticity in the associated sensory cortex, we repeatedly imaged dendritic spines and axonal varicosities of both constitutive and conditional adult ngr1 mutant mice in somatosensory barrel cortex for two weeks through cranial windows with two-photon chronic in vivo imaging. Neither constant nor acute deletion of ngr1 affected turnover or stability of dendritic spines or axonal boutons. The improved performance on the gap-cross task is not attributable to greater motor coordination, as ngr1 mutant mice possess a mild deficit in overall performance and a normal learning rate on the rotarod, a motor task. Mice lacking ngr1 also exhibit normal induction of tone-associated fear conditioning yet accelerated fear extinction and impaired consolidation. Thus, ngr1 alters tactile and motor task performance but does not appear to limit the rate of tactile or motor learning, nor determine the low set point for synaptic turnover in sensory cortex.
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影响因子：
14.8
作者：
Holtmaat, Anthony;Bonhoeffer, Tobias;Chow, David K.;Chuckowree, Jyoti;De Paola, Vincenzo;Hofer, Sonja B.;Huebener, Mark;Keck, Tara;Knott, Graham;Lee, Wei-Chung A.;Mostany, Ricardo;Mrsic-Flogel, Tom D.;Nedivi, Elly;Portera-Cailliau, Carlos;Svoboda, Karel;Trachtenberg, Joshua T.;Wilbrecht, Linda
通讯作者：
Wilbrecht, Linda
影响因子：
16.2
作者：
Holtmaat, AJGD;Trachtenberg, JT;Svoboda, K
通讯作者：
Svoboda, K
影响因子：
3.5
作者：
Barrette, Benoit;Vallieres, Nicolas;Lacroix, Steve
通讯作者：
Lacroix, Steve
影响因子：
5.3
作者：
Akbik, Feras;Cafferty, William B. J.;Strittmatter, Stephen M.
通讯作者：
Strittmatter, Stephen M.
影响因子：
5.3
作者：
Kuhlman, Sandra J.;O'Connor, Daniel H.;Svoboda, Karel
通讯作者：
Svoboda, Karel