Blood omega-3 fatty acids and death from COVID-19: A pilot study.

Blood omega-3 fatty acids and death from COVID-19: A pilot study.
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DOI:
10.1016/j.plefa.2021.102250
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发表时间:
2021-03
期刊:
Prostaglandins, leukotrienes, and essential fatty acids
影响因子:
--
通讯作者:
Harris WS
Harris WS
中科院分区:
其他
文献类型:
--
作者:
Asher A;Tintle NL;Myers M;Lockshon L;Bacareza H;Harris WS

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超长链欧米茄-3脂肪酸(EPA和DHA)具有抗炎特性,可能有助于降低COVID-19感染的发病率和死亡率。我们在100名患者中进行了一项初步研究,通过分析入院时抽取的库存血液样本中的O3 I,来检验RBC EPA+DHA水平(Omega-3指数,O3 I)与死亡风险呈负相关的假设。14例患者死亡,第4四分位数(Q4)25例中有1例(O3 I ≥5.7%),第1 -3四分位数75例中有13例。校正年龄和性别后,Q4与Q1-3 O3 I患者的死亡比值比为0.25,p = 0.07。虽然不符合统计学显著性的经典标准,但这种强烈的趋势表明,这种关系可能确实存在,但显然需要更多的有力研究。
Very-long chain omega-3 fatty acids (EPA and DHA) have anti-inflammatory properties that may help reduce morbidity and mortality from COVID-19 infection. We conducted a pilot study in 100 patients to test the hypothesis that RBC EPA+DHA levels (the Omega-3 Index, O3I) would be inversely associated with risk for death by analyzing the O3I in banked blood samples drawn at hospital admission. Fourteen patients died, one of 25 in quartile 4 (Q4) (O3I ≥5.7%) and 13 of 75 in Q1–3. After adjusting for age and sex, the odds ratio for death in patients with an O3I in Q4 vs Q1–3 was 0.25, p = 0.07. Although not meeting the classical criteria for statistical significance, this strong trend suggests that a relationship may indeed exist, but more well-powered studies are clearly needed.
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