Effect of marine-derived n-3 polyunsaturated fatty acids on C-reactive protein, interleukin 6 and tumor necrosis factor α: a meta-analysis.
Effect of marine-derived n-3 polyunsaturated fatty acids on C-reactive protein, interleukin 6 and tumor necrosis factor α: a meta-analysis.
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DOI：
10.1371/journal.pone.0088103
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Li K;Huang T;Zheng J;Wu K;Li D
关于海洋n-3多不饱和脂肪酸（PUFAs）对空腹血C反应蛋白（CRP）、白细胞介素6（IL-6）和肿瘤坏死因子α（TNF-α）水平的影响，以往的研究尚未得出一致的结论。对Web of Science、PubMed、Embase和Medline（1950年至2013年）以及相关文章的参考书目进行了全面检索。荟萃分析纳入了68项RCT，共4601例受试者。海洋来源的n-3 PUFA补充剂对三组受试者（慢性非自身免疫性疾病受试者、慢性自身免疫性疾病受试者和健康受试者）中的TNF-α、IL-6和CRP具有显著降低作用。在慢性非自身免疫性疾病受试者中，观察到海洋来源的n-3 PUFA补充的持续时间和效应大小对空腹血液TNF-α和IL-6水平的显著负线性关系，表明补充时间越长，降低效应越大。在健康受试者中也观察到IL-6水平的类似线性关系。限制性三次样条分析和亚组分析显示，当体重指数大于30 kg/m2时，海洋来源的n-3 PUFA对慢性非自身免疫性疾病受试者CRP、IL-6和TNF-α的降低作用减弱。仅在患有慢性非自身免疫性疾病的受试者中评估了来自膳食摄入的海洋来源的n-3 PUFA的作用，观察到对IL-6的显著降低作用，但对CRP和TNF-α无影响。补充海洋来源的n-3 PUFAs对CRP、IL-6和TNF-α水平具有显著的降低作用。降低效果在非肥胖受试者中最有效，建议连续长期补充。
Previous studies did not draw a consistent conclusion about the effects of marine-derived n-3 polyunsaturated fatty acids (PUFAs) on fasting blood level of C-reactive protein (CRP), interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α). A comprehensive search of Web of Science, PubMed, Embase and Medline (from 1950 to 2013) and bibliographies of relevant articles was undertaken. Sixty-eight RCTs with a total of 4601 subjects were included in the meta-analysis. Marine-derived n-3 PUFAs supplementation showed a lowering effect on Marine-derived n-3 PUFAs supplementation had a significant lowering effect on TNF-α, IL-6 and CRP in three groups of subjects (subjects with chronic non-autoimmune disease, subjects with chronic autoimmune disease and healthy subjects). A significant negative linear relationship between duration and effect size of marine-derived n-3 PUFAs supplementation on fasting blood levels of TNF-α and IL-6 in subjects with chronic non-autoimmune disease was observed, indicating that longer duration of supplementation could lead to a greater lowering effect. A similar linear relationship was also observed for IL-6 levels in healthy subjects. Restricted cubic spline analysis and subgroup analysis showed that the lowering effect of marine-derived n-3 PUFAs on CRP, IL-6 and TNF-α in subjects with chronic non-autoimmune disease became weakened when body mass index was greater than 30 kg/m2. The effect of marine-derived n-3 PUFAs from dietary intake was only assessed in subjects with chronic non-autoimmune disease, and a significant lowering effect was observed on IL-6, but not on CRP and TNF-α. Marine-derived n-3 PUFAs supplementation had a significant lowering effect on CRP, IL-6 and TNF-α level. The lowering effect was most effective in non-obese subjects and consecutive long-term supplementation was recommended.
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