Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: The Heart and Soul Study.
Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: The Heart and Soul Study.
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DOI：
10.1016/j.atherosclerosis.2008.12.013
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发表时间：
2009-08
期刊：
影响因子：
5.3
通讯作者：
Whooley, Mary A.
中科院分区：
文献类型：
--
作者：
Farzaneh-Far, Ramin;Harris, William S.;Garg, Sachin;Na, Beeya;Whooley, Mary A.
膳食摄入多不饱和n-3脂肪酸与降低不良心血管事件发生率有关。所涉及的保护机制尚不完全清楚，但可能包括抗炎因素。我们试图研究992例稳定型冠状动脉疾病患者红细胞膜中n-3脂肪酸水平与全身性炎症标志物之间的关系。c -反应蛋白（CRP）和白细胞介素-6 （Il-6）与二十二碳六烯酸（DHA）和二十碳五烯酸（EHA）的横断面相关性在多变量线性回归模型中进行了评估，调整了人口统计学、心血管危险因素、药物使用、运动能力、体重指数和腰臀比。多变量调整后，n-3脂肪酸水平（DHA + EPA）与CRP和IL-6呈负相关。n-3脂肪酸与CRP和IL-6的负相关关系不受人口统计学、体重指数、吸烟、低密度脂蛋白胆固醇或他汀类药物使用的影响（相互作用的p值为>.1）。在稳定性冠状动脉疾病患者中，n-3脂肪酸水平与炎症生物标志物之间存在独立的负相关关系。这些发现表明，抑制全身性炎症可能是n-3脂肪酸预防心血管事件复发的机制。
Dietary intake of polyunsaturated n-3 fatty acids has been associated with a reduced incidence of adverse cardiovascular events. The protective mechanisms involved are not fully understood, but may include anti-inflammatory factors. We sought to investigate the relationship between n-3 fatty acid levels in erythrocyte membranes and markers of systemic inflammation in 992 individuals with stable coronary artery disease. Cross-sectional associations of C-reactive protein (CRP) and Interleukin-6 (Il-6) with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EHA) were evaluated in multivariable linear regression models adjusted for demographics, cardiovascular risk factors, medication use, exercise capacity, body mass index, and waist-to-hip ratio. After multivariable adjustment, n-3 fatty acid levels (DHA + EPA) were inversely associated with CRP and IL-6. The inverse association of n-3 fatty acids with CRP and IL-6 was not modified by demographics, body-mass index, smoking, LDL-cholesterol, or statin use (p values for interaction > 0.1) In patients with stable coronary artery disease, an independent and inverse association exists between n-3 fatty acid levels and inflammatory biomarkers. These findings suggest that inhibition of systemic inflammation may be a mechanism by which n-3 fatty acids prevent recurrent cardiovascular events.
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影响因子：
15.8
作者：
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影响因子：
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作者：
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