Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice.
Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice.
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DOI：
10.1038/srep03273
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发表时间：
2013-11-20
影响因子：
4.6
通讯作者：
Nakaya, Haruaki
中科院分区：
文献类型：
--
作者：
Matsumoto, Akio;Yamafuji, Megumi;Tachibana, Tomoko;Nakabeppu, Yusaku;Noda, Mami;Nakaya, Haruaki
分子氢（H2）的治疗潜力正在许多人类疾病及其动物模型中出现，特别是包括帕金森病（PD）。饮用水中补充H2已被证明对PD患者具有改善疾病的作用，并对PD模型小鼠具有神经保护作用。然而，补充H2不会导致纹状体H2水平的可检测变化，表明间接影响。本研究表明，H2的补充增加了胃促生长素（一种生长激素促分泌素）编码mRNA的表达和胃促生长素的分泌，而胃促生长素的分泌可被β1-肾上腺素受体阻滞剂阿替洛尔拮抗。引人注目的是，H2水的神经保护作用被ghrelin受体拮抗剂D-Lys3 GHRP-6或阿替洛尔所消除。因此，H2在PD中的神经保护作用是通过增强胃饥饿素的产生来介导的。我们的研究结果指出了改善病理生理的潜在的新策略，其中补充H2的保护作用已被证明。
The therapeutic potential of molecular hydrogen (H2) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H2 supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H2 supplementation does not result in detectable changes in striatal H2 levels, indicating an indirect effect. Here we show that H2 supplementation increases gastric expression of mRNA encoding ghrelin, a growth hormone secretagogue, and ghrelin secretion, which are antagonized by the β1-adrenoceptor blocker, atenolol. Strikingly, the neuroprotective effect of H2 water was abolished by either administration of the ghrelin receptor-antagonist, D-Lys3 GHRP-6, or atenolol. Thus, the neuroprotective effect of H2 in PD is mediated by enhanced production of ghrelin. Our findings point to potential, novel strategies for ameliorating pathophysiology in which a protective effect of H2 supplementation has been demonstrated.
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影响因子：
2.9
作者：
Ito M;Hirayama M;Yamai K;Goto S;Ito M;Ichihara M;Ohno K
通讯作者：
Ohno K
DOI：
10.1523/jneurosci.3890-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andrews ZB;Erion D;Beiler R;Liu ZW;Abizaid A;Zigman J;Elsworth JD;Savitt JM;DiMarchi R;Tschoep M;Roth RH;Gao XB;Horvath TL
通讯作者：
Horvath TL
DOI：
10.1016/j.bbrc.2007.07.088
发表时间：
2007-09-28
影响因子：
3.1
作者：
Fukuda, Kei-Ichi;Asoh, Sadamitsu;Ohta, Shigeo
通讯作者：
Ohta, Shigeo
影响因子：
2.9
作者：
Kang KM;Kang YN;Choi IB;Gu Y;Kawamura T;Toyoda Y;Nakao A
通讯作者：
Nakao A
影响因子：
4.8
作者：
Gagnon, Jeffrey;Anini, Younes
通讯作者：
Anini, Younes