Recurrent seizures induce a reversible impairment in a spatial hidden goal task.
Recurrent seizures induce a reversible impairment in a spatial hidden goal task.
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反复发作会导致空间隐藏目标任务的可逆性损伤。
DOI：
10.1002/hipo.20565
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发表时间：
2009-09
期刊：
影响因子：
3.5
通讯作者：
Muller, Robert U.
中科院分区：
文献类型：
--
作者：
Lin, Hai;Holmes, Gregory L.;Kubie, John L.;Muller, Robert U.
关于癫痫的学习和记忆缺陷特征的一个主要问题是导致反复发作的初始损伤与癫痫发作本身的相对重要性。一个相关的问题是，当抽搐停止时，癫痫引起的认知能力下降是永久性的还是可逆的。为了解决这些问题，成年大鼠在“空间准确性任务”中进行了广泛的训练，这是莫里斯水迷宫的旱地模拟。这项任务允许大鼠对隐藏目标区位置的估计在每个行为会话中重复测量。一个目的是测量，在训练有素的动物，任何认知障碍所造成的每日氟乙烯诱导的全身癫痫发作超过11天的时间过程。第二个目标是在随后的9天内寻找可能的恢复，没有癫痫发作。我们看到在癫痫发作期间空间表现的累积退化，并且在癫痫发作停止后赤字逆转，使得表现恢复到基线。有趣的是，学习到渐近线的速度，每天一次癫痫发作期间的性能下降速度以及恢复期间的重新学习速度都是相似的。鉴于海马体在空间记忆中起着重要的作用，而且它是最容易受到异常兴奋影响的大脑结构，这意味着海马体即使在定位固定目标区域的长期训练之后，仍然对精确的空间导航至关重要。在临床上，这一发现质疑了癫痫发作患者应在数小时内恢复到基线认知水平的假设。
A major question concerning the learning and memory deficits characteristic of epilepsy is the relative importance of the initial insult that leads to recurrent, unprovoked seizures versus the seizures themselves. A related issue is whether seizure-induced cognitive decline is permanent or reversible when convulsions cease. To address these problems, adult rats were extensively trained in the “spatial accuracy task”, a dry-land analog of the Morris water maze. This task allows the rat’s estimate of the location of a hidden goal zone to be repeatedly measured within each behavioral session. One aim was to measure, in well-trained animals, the time course of any cognitive impairment caused by a daily flurothyl-induced generalized seizure over 11 days. A second aim was to look for possible recovery during 9 subsequent days with no seizures. We saw a cumulative degradation in spatial performance during the seizure days and reversal of the deficit after seizures were stopped such that performance returned to baseline. Interestingly, the rate of learning to an asymptote, the rate of performance decline during one-per-day seizures and the rate of relearning during the recovery period were all similar. Given that the hippocampus plays an important role in spatial memory and that it is the brain structure most vulnerable to abnormal excitation the implication is that the hippocampus remains essential for precise spatial navigation even after prolonged training in locating a fixed goal zone. Clinically, this finding questions the assumption that patients who experience seizures should return to a baseline cognitive level within hours.
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DOI：
10.1085/jgp.116.2.191
发表时间：
2000-08
期刊：
The Journal of general physiology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.3
作者：
Hok, Vincent;Lenck-Santini, Pierre-Pascal;Poucet, Bruno
通讯作者：
Poucet, Bruno
影响因子：
2.7
作者：
Packard, MG;McGaugh, JL
通讯作者：
McGaugh, JL
影响因子：
11
作者：
Jokeit, H;Ebner, A
通讯作者：
Ebner, A
影响因子：
25
作者：
Vyazovskiy, Vladyslav V.;Cirelli, Chiara;Tononi, Giulio
通讯作者：
Tononi, Giulio