Coffee with High but Not Low Caffeine Content Augments Fluid and Electrolyte Excretion at Rest.
Coffee with High but Not Low Caffeine Content Augments Fluid and Electrolyte Excretion at Rest.
复制标题
DOI：
10.3389/fnut.2017.00040
复制
发表时间：
2017
影响因子：
5
通讯作者：
Kavouras SA
中科院分区：
文献类型：
--
作者：
Seal AD;Bardis CN;Gavrieli A;Grigorakis P;Adams JD;Arnaoutis G;Yannakoulia M;Kavouras SA
低剂量的咖啡因摄入在休息时不会导致脱水，然而较大剂量是否具有急性利尿作用尚不明确。本研究的目的是通过咖啡来检验低剂量和高剂量咖啡因对习惯喝咖啡者（每天至少一杯）在休息时的体液平衡的急性影响。
10名健康成年人（8名男性和2名女性；年龄：27 ± 5岁，体重：89.5 ± 14.8 kg，身高：1.75 ± 0.08 m，身体质量指数：29.1 ± 4.4 kg/m²）在三个不同的场合分别摄入200 mL水（W）、低咖啡因咖啡（3 mg/kg，LCAF）或高咖啡因咖啡（6 mg/kg，HCAF）。所有实验均在上午09:00以平衡、交叉的方式进行，每次间隔至少5天。受试者留在实验室，在摄入后3小时内每60分钟收集一次尿液样本。
LCAF和HCAF的绝对咖啡因摄入量分别为269 ± 45 mg和537 ± 89 mg。与W（356 ± 53 mL）和LCAF（316 ± 38 mL）相比，HCAF试验中的咖啡摄入在3小时内诱导了更强的利尿作用（613 ± 101 mL，P < 0.05）。此外，与W（249 ± 36 mmol）和LCAF（177 ± 16 mmol）试验相比，HCAF试验中的累积尿渗透压排泄量显著更高（425 ± 92 mmol，P < 0.05）。
数据表明，以咖啡形式摄入6 mg/kg的咖啡因可诱导急性利尿作用，而3 mg/kg的咖啡因不会干扰健康的偶尔喝咖啡的成年人在休息时的体液平衡。
Low levels of caffeine ingestion do not induce dehydration at rest, while it is not clear if larger doses do have an acute diuretic effect. The aim of the present investigation was to examine the acute effect of low and high levels of caffeine, via coffee, on fluid balance in habitual coffee drinkers (at least one per day) at rest. Ten healthy adults (eight males and two females; age: 27 ± 5 years, weight: 89.5 ± 14.8 kg, height: 1.75 ± 0.08 m, and body mass index: 29.1 ± 4.4 kg m−2) ingested 200 mL of water (W), coffee with low caffeine (3 mg kg−1, LCAF), or coffee with high caffeine (6 mg kg−1, HCAF) on three respective separate occasions. All sessions were performed at 09:00 in the morning in a counterbalanced, crossover manner, at least 5 days apart. Subjects remained in the laboratory while urine samples were collected every 60 min for 3 h post ingestion. Absolute caffeine consumption was 269 ± 45 and 537 ± 89 mg for the LCAF and HCAF, respectively. Coffee ingestion at the HCAF trial induced greater diuresis during the 3-h period (613 ± 101 mL, P < 0.05), when compared to W (356 ± 53 mL) and LCAF (316 ± 38 mL). In addition, cumulative urinary osmotic excretion was significantly greater in the HCAF (425 ± 92 mmol, P < 0.05), as compared to the W (249 ± 36 mmol) and LCAF (177 ± 16 mmol) trials. The data indicate that caffeine intake of 6 mg kg−1 in the form of coffee can induce an acute diuretic effect, while 3 mg kg−1 do not disturb fluid balance in healthy casual coffee drinking adults at rest.
登录
查看更多内容
DOI：
10.1056/nejmoa1112010
发表时间：
2012-05-17
期刊：
The New England journal of medicine
影响因子：
--
作者：
Freedman ND;Park Y;Abnet CC;Hollenbeck AR;Sinha R
通讯作者：
Sinha R
影响因子：
6.1
作者：
Popkin BM;D'Anci KE;Rosenberg IH
通讯作者：
Rosenberg IH
DOI：
10.1123/ijsnem.15.3.252
发表时间：
2005-06-01
影响因子：
2.5
作者：
Armstrong, LE;Pumerantz, AC;Kellogg, M
通讯作者：
Kellogg, M
影响因子：
2.5
作者：
Wemple, RD;Lamb, DR;McKeever, KH
通讯作者：
McKeever, KH
影响因子：
4.7
作者：
Grosso, Giuseppe;Marventano, Stefano;Mistretta, Antonio
通讯作者：
Mistretta, Antonio