Clinical Significance and Integrative Analysis of the SMC Family in Hepatocellular Carcinoma.
Clinical Significance and Integrative Analysis of the SMC Family in Hepatocellular Carcinoma.
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SMC家族在肝细胞癌中的临床意义及综合分析
DOI：
10.3389/fmed.2021.727965
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发表时间：
2021
影响因子：
3.9
通讯作者：
Ou C
中科院分区：
文献类型：
--
作者：
Nie H;Wang Y;Yang X;Liao Z;He X;Zhou J;Ou C
在世界范围内，肝细胞癌是恶性程度最高、预后差的癌症之一。染色体结构维持(SMC)基因家族在人类癌症中起着重要作用。然而，SMC成员在肝细胞癌中的作用还没有被很好地理解。在这项研究中，我们使用一系列生物信息学分析工具全面探讨了SMC家族在肝细胞癌中的作用。研究表明，SMC1A、SMC1B、SMC2、SMC4和SMC6的mRNA表达水平在肝癌组织中显著过表达，SMC1A、SMC2、SMC3、SMC4、SMC5和SMC6的蛋白表达水平也明显升高。此外，SMC2和SMC4高表达的肝细胞癌患者存活率较低。利用KEGG和GO分析，我们分析了SMC家族在肝细胞癌中的生物学功能和途径中基因表达的丰富。免疫浸润分析显示，SMC家族的表达与B细胞、CD4+T细胞、CD8+T细胞、巨噬细胞、中性粒细胞和DC密切相关。综上所述，我们的发现将加深对SMC家族在肝癌进展过程中的深入了解，并为未来肝细胞癌的诊断和治疗提供新的方向。
Worldwide, hepatocellular carcinoma (HCC) is one of the most malignant cancers with poor prognosis. The structural maintenance of chromosomes (SMC) gene family has been shown to play important roles in human cancers. Nevertheless, the role of SMC members in HCC is not well-understood. In this study, we comprehensively explored the role of the SMC family in HCC using a series of bioinformatic analysis tools. Studies have demonstrated that the mRNA expression levels of SMC1A, SMC1B, SMC2, SMC4, and SMC6 are significantly overexpressed in HCC, and the protein levels of SMC1A, SMC2, SMC3, SMC4, SMC5, and SMC6 are similarly elevated. Moreover, HCC patients with high SMC2 and SMC4 expression levels exhibit poor survival. Using KEGG and GO analyses, we analyzed the enrichment of gene expression in the biological functions and pathways of the SMC family in HCC. Immune infiltration analysis revealed that the expression of the SMC family is closely associated with B cells, CD4+ T cells, CD8+ T cells, macrophages, neutrophils, and DCs. In conclusion, our findings will enhance a more thorough understanding of the SMC family in HCC progression and provide new directions for the diagnosis and treatment of HCC in the future.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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