CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses.
CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses.
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DOI：
10.1084/jem.20100098
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发表时间：
2010-08-30
期刊：
影响因子：
--
通讯作者：
Tellides G
中科院分区：
文献类型：
--
作者：
Zhou J;Tang PC;Qin L;Gayed PM;Li W;Skokos EA;Kyriakides TR;Pober JS;Tellides G
血流的持续变化通过血管壁的结构改变来调节导管动脉的大小，而血管壁的结构改变取决于血管周围巨噬细胞的瞬时积累和激活。白细胞浸润似乎仅限于外膜，负责内侧重塑，一旦血流动力学压力恢复正常而没有明显的内膜变化，白细胞浸润就会消失。我们报道，结扎同侧颈外动脉后，小鼠颈总动脉的向内重塑依赖于趋化因子受体CXCR3。野生型骨髓细胞在CXCR3缺陷的受体中恢复了血流介导的血管重塑，Gr1low驻留表型的外膜浸润巨噬细胞表达CXCR3，巨噬细胞的血管周围积聚依赖于CXCR3信号传导，并且CXCR3配体IP-10足以将单核细胞募集到外膜。 CXCR3 还有助于细胞外基质周转所需的巨噬细胞激活的选择性特征，例如转谷氨酰胺酶因子 XIII A 亚基的产生。人外膜巨噬细胞表现出 CD14+/CD16+ 驻留表型，但循环单核细胞不表达 CXCR3，并且此类细胞在血流紊乱的部位更为常见。我们的观察表明，血管周围巨噬细胞依赖于 CXCR3 的积累和激活，是小鼠（也可能是人类）血流动力学应激引发的稳态动脉重塑的必要步骤。
Sustained changes in blood flow modulate the size of conduit arteries through structural alterations of the vessel wall that are dependent on the transient accumulation and activation of perivascular macrophages. The leukocytic infiltrate appears to be confined to the adventitia, is responsible for medial remodeling, and resolves once hemodynamic stresses have normalized without obvious intimal changes. We report that inward remodeling of the mouse common carotid artery after ligation of the ipsilateral external carotid artery is dependent on the chemokine receptor CXCR3. Wild-type myeloid cells restored flow-mediated vascular remodeling in CXCR3-deficient recipients, adventitia-infiltrating macrophages of Gr1low resident phenotype expressed CXCR3, the perivascular accumulation of macrophages was dependent on CXCR3 signaling, and the CXCR3 ligand IP-10 was sufficient to recruit monocytes to the adventitia. CXCR3 also contributed to selective features of macrophage activation required for extracellular matrix turnover, such as production of the transglutaminase factor XIII A subunit. Human adventitial macrophages displaying a CD14+/CD16+ resident phenotype, but not circulating monocytes, expressed CXCR3, and such cells were more frequent at sites of disturbed flow. Our observations reveal a CXCR3-dependent accumulation and activation of perivascular macrophages as a necessary step in homeostatic arterial remodeling triggered by hemodynamic stress in mice and possibly in humans as well.
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影响因子：
3.7
作者：
Gratchev, A;Kzhyshkowska, J;Goerdt, S
通讯作者：
Goerdt, S
影响因子：
20.1
作者：
Bakker, Erik N. T. P.;Pistea, Adrian;VanBavel, Ed
通讯作者：
VanBavel, Ed
DOI：
10.1084/jem.192.10.1515
发表时间：
2000-11-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hancock WW;Lu B;Gao W;Csizmadia V;Faia K;King JA;Smiley ST;Ling M;Gerard NP;Gerard C
通讯作者：
Gerard C
在动脉粥样硬化之前和开发过程中淋巴细胞募集到主动脉壁是部分依赖性L-选择蛋白。
DOI：
10.1084/jem.20052205
发表时间：
2006-05-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.6
作者：
le Noble, F;Moyon, D;Eichmann, A
通讯作者：
Eichmann, A