The Impact of Location of Progressive Visual Field Loss on Longitudinal Changes in Quality of Life of Patients with Glaucoma.
The Impact of Location of Progressive Visual Field Loss on Longitudinal Changes in Quality of Life of Patients with Glaucoma.
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DOI：
10.1016/j.ophtha.2015.10.046
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发表时间：
2016-03
期刊：
影响因子：
13.7
通讯作者：
Medeiros FA
中科院分区：
文献类型：
--
作者：
Abe RY;Diniz-Filho A;Costa VP;Gracitelli CP;Baig S;Medeiros FA
评价视野不同区域的进行性丧失率与生活质量（QoL）纵向变化之间的相关性。前瞻性观察性队列研究。该研究纳入了236例平均随访4.3 ± 1.5年的昏迷性视野丧失患者。所有受试者每年进行一次国家眼科研究所视觉功能调查问卷（NEI VFQ-25），每6个月进行一次标准自动视野检查（SAP）。如果受试者在随访期间至少进行了2次NEI VFQ-25和5次SAP测试，则纳入受试者。使用整合双眼视野的4个不同区域（中央下、中央上级、周边下和周边上级）进行视野变化率的评价。使用联合多变量纵向线性混合模型研究了NEI VFQ-25 Rasch校准评分的变化与视野不同区域变化之间的关联。生活质量评分变化与视野不同区域平均敏感度变化之间的关系。随访期间NEI VFQ-25 Rasch评分的变化与视野不同区域的变化之间存在显著相关性。中央下区双眼平均敏感度每变化1dB/年，NEI VFQ-25评分下降2.6个单位/年（R2= 35%; P<0.001）。相应的相关性与周边下部、中央上级和周边上级视野区域的生活质量评分变化的相关性分别为30%、24%和19%。中央下视野区的相关性在统计学上显著强于中央上级区（P=0.011）和周边上级区（P= 0.001），但周边下视野区的相关性不强（P=0.171）。在基线时视野敏感性较差的患者中，NEI VFQ-25评分也出现了较大幅度的下降。视野中央下区敏感度的进行性下降与青光眼患者生活质量的纵向下降相关性最强。
To evaluate the association between rates of progressive loss in different regions of the visual field and longitudinal changes in quality of life (QoL). Prospective observational cohort study. The study included 236 patients with glaucomatous visual field loss followed for an average of 4.3 ± 1.5 years. All subjects had National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) performed annually and standard automated perimetry (SAP) at 6-month intervals. Subjects were included if they had a minimum of 2 NEI VFQ-25 and 5 SAP tests during follow-up. Evaluation of rates of visual field change was performed using 4 different regions (central inferior, central superior, peripheral inferior, and peripheral superior) of the integrated binocular visual field. The association between change in NEI VFQ-25 Rasch-calibrated scores and change in different regions of the visual field was investigated with a joint multivariable longitudinal linear mixed model. The relationship between change in QoL scores and change of mean sensitivity in different regions of the visual field. There was a significant correlation between change in the NEI VFQ-25 Rasch scores during follow-up and change in different regions of the visual field. Each 1dB/year change in binocular mean sensitivity of the central inferior area was associated with a decline of 2.6 units/year in the NEI VFQ-25 scores (R2= 35%; P<0.001). Corresponding associations with change in QoL scores for the peripheral inferior, central superior and peripheral superior areas of the visual field had R2 values of 30%, 24% and 19%, respectively. The association for the central inferior visual field area was statistically significantly stronger than those of central superior (P=0.011) and peripheral superior area (P= 0.001), but not the peripheral inferior area (P=0.171). Greater declines in NEI VFQ-25 scores were also seen in those patients who had worse visual field sensitivity at baseline. Progressive decline in sensitivity in the central inferior area of the visual field had the strongest association with longitudinal decline in QoL of glaucoma patients.
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DOI：
10.1001/jama.2014.3192
发表时间：
2014-05-14
期刊：
JAMA
影响因子：
--
作者：
Weinreb RN;Aung T;Medeiros FA
通讯作者：
Medeiros FA
影响因子：
13.7
作者：
Medeiros, Felipe A.;Gracitelli, Carolina P. B.;Boer, Erwin R.;Weinreb, Robert N.;Zangwill, Linda M.;Rosen, Peter N.
通讯作者：
Rosen, Peter N.
影响因子：
4.2
作者：
Boden, C;Blumenthal, EZ;Sample, PA
通讯作者：
Sample, PA
影响因子：
13.7
作者：
Tham, Yih-Chung;Li, Xiang;Cheng, Ching-Yu
通讯作者：
Cheng, Ching-Yu
影响因子：
13.7
作者：
Freeman, Ellen E.;Munoz, Beatriz;Friedman, David S.
通讯作者：
Friedman, David S.