Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver.
Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver.
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DOI：
10.1038/s41598-018-30267-2
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发表时间：
2018-08-06
影响因子：
4.6
通讯作者：
Kuwabara M
中科院分区：
文献类型：
--
作者：
Jensen T;Niwa K;Hisatome I;Kanbay M;Andres-Hernando A;Roncal-Jimenez CA;Sato Y;Garcia G;Ohno M;Lanaspa MA;Johnson RJ;Kuwabara M
脂肪肝（FLD）的患病率正在上升。为了弄清发生FLD的危险因素，我们分析了一个来自健康日本成年人的数据库，这些成年人在2004年进行了年度体检，并在2009年进行了复查。我们使用脂肪肝指数（FLI）将参与者分为脂肪肝（FLI≥60）、边缘性脂肪肝（30≤FLI <60）和正常肝脏（FLI <30）。排除乙型或丙型肝炎病毒感染和基线时患有FLD的受试者。正常肝脏FLD和边缘性FLD 5年累积发病率分别为0.65%（52/ 8025）和12.9%（244/ 1888）。经过多次调整，较高的血清尿酸（SUA） （OR:1.92; 95% CI: 1.40-2.63）和增加的SUA变化（OR:3.734; 95% CI: 2.57-5.42）成为正常肝脏发生FLD的危险因素，以及年龄更小和体重指数更高。从边缘性FLD发展为FLD的危险因素相似。基线SUA升高和SUA变化增加都是发生FLD的独立危险因素。
The prevalence of fatty liver disease (FLD) is increasing. To clarify risk factors for developing FLD, we analyzed a database from healthy Japanese adults who had annual medical check-ups in 2004 and reexamined in 2009. We used the fatty liver index (FLI) to classify participants as FLD (FLI ≥60), borderline FLD (30≤ FLI <60), and normal liver (FLI <30). Subjects with hepatitis B or C virus infection and subjects with FLD at the baseline were excluded. The cumulative incidence of FLD from normal liver and from borderline FLD over five years were 0.65% (52/8,025) and 12.9% (244/1,888), respectively. After multiple adjustments, higher serum uric acid (SUA) (OR:1.92; 95% CI:1.40–2.63) and increased SUA change (OR:3.734; 95% CI:2.57–5.42) became risk factors for developing FLD from normal liver, as well as younger age and higher body mass index. The risk factors for developing FLD from borderline FLD were similar. Not only higher baseline SUA but also increased SUA change became independent risks for developing FLD.
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影响因子：
4.5
作者：
Akter S;Nanri A;Pham NM;Kurotani K;Mizoue T
通讯作者：
Mizoue T
DOI：
10.1016/j.numecd.2014.06.002
发表时间：
2014-12
期刊：
Nutrition, metabolism, and cardiovascular diseases : NMCD
影响因子：
--
作者：
Ferrara LA;Wang H;Umans JG;Franceschini N;Jolly S;Lee ET;Yeh J;Devereux RB;Howard BV;de Simone G
通讯作者：
de Simone G
影响因子：
37.8
作者：
Black, Henry R.;Sica, Domenic;White, William B.
通讯作者：
White, William B.
影响因子：
25.7
作者：
Li, Youming;Xu, Chengfu;Miao, Min
通讯作者：
Miao, Min
DOI：
10.1161/hypertensionaha.116.08998
发表时间：
2017-06
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Kuwabara M;Niwa K;Hisatome I;Nakagawa T;Roncal-Jimenez CA;Andres-Hernando A;Bjornstad P;Jensen T;Sato Y;Milagres T;Garcia G;Ohno M;Lanaspa MA;Johnson RJ
通讯作者：
Johnson RJ