Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal?
Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal?
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DOI：
10.1007/s11906-013-0344-5
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发表时间：
2013-06
影响因子：
5.6
通讯作者：
Reisin, Efrain
中科院分区：
文献类型：
--
作者：
Soltani, Zohreh;Rasheed, Kashaf;Kapusta, Daniel R.;Reisin, Efrain
关键词：
血清尿酸浓度升高是代谢综合征/肥胖、高血压、肾脏疾病和心血管事件受试者的常见实验室检查结果。高尿酸血症被归因于代谢综合征中的高胰岛素血症和肾功能不全中的尿酸排泄减少，并且不被认为是代谢综合征、肾脏疾病和心血管疾病发展的主要介质。然而，最近的研究改变了这一传统观点，并提供了令人信服的证据，支持高尿酸血症与代谢综合征、糖尿病、高血压、肾脏疾病和心血管疾病风险增加之间的独立联系。然而，尽管有这些新的发现，关于尿酸在诱发这些疾病中的确切作用的争议仍有待展开。此外，最近的数据表明，美国的高果糖饮食作为高尿酸血症的主要原因，可能导致代谢综合征/肥胖症流行、糖尿病、高血压、肾脏疾病和心血管疾病。我们在这篇综述中的重点是讨论现有的证据支持尿酸在代谢综合征，高血压，肾脏疾病和心血管疾病的发展中的作用;以及涉及的潜在病理生理机制。
Elevated serum uric acid concentration is a common laboratory finding in subjects with metabolic syndrome/obesity, hypertension, kidney disease and cardiovascular events. Hyperuricemia has been attributed to hyperinsulinemia in metabolic syndrome and to decreased uric acid excretion in kidney dysfunction and is not acknowledged as a main mediator of metabolic syndrome, renal disease, and cardiovascular disorder development. However, more recent investigations have altered this traditional view and shown by providing compelling evidence to support an independent link between hyperuricemia and increased risk of metabolic syndrome, diabetes, hypertension, kidney disease and cardiovascular disorders. However, despite these new findings, controversy regarding the exact role of uric acid in inducing these diseases remains to be unfolded. Furthermore, recent data suggest that the high-fructose diet in the United State, as a major cause of hyperuricemia, may be contributing to the metabolic syndrome/obesity epidemic, diabetes, hypertension, kidney disease and cardiovascular disorder. Our focus in this review is to discuss the available evidence supporting a role for uric acid in the development of metabolic syndrome, hypertension, renal disease, and cardiovascular disorder; and the potential pathophysiology mechanisms involved.
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