Signal detection analysis of blindsight in monkeys.
Signal detection analysis of blindsight in monkeys.
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DOI：
10.1038/srep10755
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发表时间：
2015-05-29
影响因子：
4.6
通讯作者：
Isa T
中科院分区：
文献类型：
--
作者：
Yoshida M;Isa T
V1 单侧病变的猕猴已被用作盲视动物模型。虽然盲视的客观证明要求盲视的两个方面（残余强制选择定位和减弱是/否检测）应在相同的刺激条件下使用无偏差的敏感性测量进行测试，但在非人类灵长类动物的研究中尚未实现这些目标。在这里，我们测试了两只患有单侧 V1 病变的猕猴，并使用相同的刺激执行两项扫视任务：强制选择（FC）任务和是-否（YN）任务。基于信号检测理论的分析表明，FC任务的灵敏度显着高于YN任务。当在正常、未受影响的半视野中出现接近阈值的视觉刺激时，没有观察到这两项任务之间的敏感性分离。这些结果表明，V1 受损的猴子类似于经过充分研究的盲视患者 G.Y.，其视觉体验本身已完全消失。
Macaque monkeys with a unilateral lesion in V1 have been used as an animal model of blindsight. While objective proof of blindsight requires that the two aspects of blindsight (residual forced-choice localization and attenuated yes-no detection) should be tested under identical stimulus conditions using bias-free measures of sensitivity, these have not been attained in studies of nonhuman primates. Here we tested two macaque monkeys with a unilateral V1 lesion with two saccade tasks using identical stimuli: a forced-choice (FC) task and a yes-no (YN) task. An analysis based on signal detection theory revealed that sensitivity in the FC task was significantly higher than that in the YN task. Such dissociation of sensitivity between the two tasks was not observed when near-threshold visual stimuli were presented in the normal, unaffected hemifield. These results suggest that the V1-lesioned monkeys resemble the well-studied blindsight patient G.Y., whose visual experience per se was completely abolished.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
2.4
作者：
Azzopardi, P;Cowey, A
通讯作者：
Cowey, A
DOI：
10.1098/rstb.2011.0380
发表时间：
2012-05-19
影响因子：
6.3
作者：
Ko, Yoshiaki;Lau, Hakwan
通讯作者：
Lau, Hakwan
影响因子：
25
作者：
Persaud, Navindra;McLeod, Peter;Cowey, Alan
通讯作者：
Cowey, Alan
DOI：
10.1073/pnas.92.18.8215
发表时间：
1995-08-29
影响因子：
11.1
作者：
MOORE, T;RODMAN, HR;GROSS, CG
通讯作者：
GROSS, CG