Manganese-enhanced MRI of salivary glands and head and neck tumors in living subjects.
Manganese-enhanced MRI of salivary glands and head and neck tumors in living subjects.
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DOI：
10.1002/mrm.22452
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发表时间：
2010-09
影响因子：
3.3
通讯作者：
Hoy A
中科院分区：
文献类型：
--
作者：
Seshadri M;Hoy A
锰增强 MRI 此前曾用于大脑结构的可视化和神经通路的功能映射。目前的工作研究了锰增强 MRI 对活体唾液腺进行无创成像的潜力。全身给予 MnCl2（0.4 mmol/kg，腹膜内注射）后 24-48 小时，在初始小鼠 (n = 5) 的唾液腺中观察到 T1 显着缩短。三维磁共振显微镜证实了注射 MnCl2 后唾液腺组织的选择性对比增强。异位和原位头颈肿瘤异种移植物在注射 MnCl2（0.2 mmol/kg，腹膜内）后 24 小时也显示 R1 增加。然而，与唾液腺组织相比，肿瘤增强很小。与未经处理的小鼠相比，患有原位头颈肿瘤的小鼠的唾液腺 R1 值较低。这些结果首次证明了锰增强 MRI 在体内唾液腺和头颈肿瘤可视化方面的有用性。
Manganese-enhanced MRI has previously been used for visualization of brain architecture and functional mapping of neural pathways. The present work investigated the potential of manganese-enhanced MRI for noninvasive imaging of salivary glands in living subjects. Marked shortening of T1 was observed in salivary glands of naïve mice (n = 5) 24–48 h after systemic administration of MnCl2 (0.4 mmol/kg, intraperitoneally). Three-dimensional MR microscopy confirmed selective contrast enhancement of salivary gland tissues post–MnCl2 injection. Ectopic and orthotopic head and neck tumor xenografts also showed an increase in R1 at 24 h following MnCl2 injection (0.2 mmol/kg, intraperitoneally). However, tumor enhancement was minimal compared to salivary gland tissue. Salivary gland R1 values were lower in mice bearing orthotopic head and neck tumors compared to naïve mice. These results demonstrate, for the first time, the usefulness of manganese-enhanced MRI in the visualization of salivary glands and head and neck tumors in vivo.
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