A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems.
A Review on Biomedical Application of Polysaccharide-Based Hydrogels with a Focus on Drug Delivery Systems.
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DOI：
10.3390/polym14245432
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发表时间：
2022-12-12
期刊：
影响因子：
5
通讯作者：
Yazdani Nezhad H
中科院分区：
文献类型：
--
作者：
Farasati Far B;Naimi-Jamal MR;Safaei M;Zarei K;Moradi M;Yazdani Nezhad H
在过去几年的药物递送系统（DDS）研究中，天然聚合物基水凝胶由于其固有的性质和广泛的潜在应用而显示出许多科学进展。虽然药物疗效和细胞毒性起着关键作用，但采用合适的DDS对于保持药物沿着给药途径并在靶向部位具有所需的治疗效果至关重要。因此，药物递送技术可用于克服将药物长时间维持在生理相关血清浓度的困难。由于其突出的生物相容性，多糖已被彻底研究作为生物材料的DDS的进步。为了配制改良的DDS，多糖可以与不同的分子交联，从而形成水凝胶。根据我们最近的研究结果，由于外部刺激，如温度，pH值，葡萄糖或光，在某一点发生靶向药物递送。作为一种可调节的生物医学器件，水凝胶在涉及健康领域如制药和生物医学工程的纳米技术应用中具有巨大的潜力。综述了水凝胶的特性和功能。我们重点讨论了各种水凝胶为基础的系统，其有效地提供药物的潜力是由多糖。
Over the last years of research on drug delivery systems (DDSs), natural polymer-based hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper DDS is crucial to preserve the drug along the route of administration and possess desired therapeutic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a biological material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-link with different molecules, resulting in hydrogels. According to our recent findings, targeted drug delivery at a certain spot occurs due to external stimulation such as temperature, pH, glucose, or light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech applications in involved health areas such as pharmaceutical and biomedical engineering. An overview of hydrogel characteristics and functionalities is provided in this review. We focus on discussing the various kinds of hydrogel-based systems on their potential for effectively delivering drugs that are made of polysaccharides.
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影响因子：
16.6
作者：
Bian Q;Fu L;Li H
通讯作者：
Li H
局部应用水凝胶脂质体进行系统靶向肿瘤光热治疗
影响因子：
6
作者：
Chen G;Ullah A;Xu G;Xu Z;Wang F;Liu T;Su Y;Zhang T;Wang K
通讯作者：
Wang K
DOI：
10.1016/j.jddst.2022.103144
发表时间：
2022-02-08
影响因子：
5
作者：
Ali, Arshad;Hussain, Muhammad Ajaz;Sheikh, Fatima Akbar
通讯作者：
Sheikh, Fatima Akbar
水凝胶的多功能性：从合成策略，分类和特性到生物医学应用。
DOI：
10.3390/gels8030167
发表时间：
2022-03-07
期刊：
Gels (Basel, Switzerland)
影响因子：
--
作者：
Ahmad Z;Salman S;Khan SA;Amin A;Rahman ZU;Al-Ghamdi YO;Akhtar K;Bakhsh EM;Khan SB
通讯作者：
Khan SB
影响因子：
11.1
作者：
Alibak, Ali Hosin;Khodarahmi, Mohsen;Aminzadehsarikhanbeglou, Elnaz
通讯作者：
Aminzadehsarikhanbeglou, Elnaz