Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance.
Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance.
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前驱、首发和慢性精神病中的神经心理损伤：评估 RBANS 表现。
DOI：
10.1371/journal.pone.0125784
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Zhang T;Li H;Stone WS;Woodberry KA;Seidman LJ;Tang Y;Guo Q;Zhuo K;Qian Z;Cui H;Zhu Y;Jiang L;Chow A;Tang Y;Li C;Jiang K;Yi Z;Xiao Z;Wang J
认知缺陷贯穿于精神病的所有发展阶段。然而，先前的研究通常集中在有限的疾病期间，并使用了各种各样的认知工具。因此，很难描述或强调不同阶段精神病的认知功能。我们对4个参与者亚组进行了rban（可重复神经心理状态评估电池）测试，包括健康志愿者（对照组，HC, n = 28）、临床精神病高危受试者（前体症状，CHR, n = 27）、首发精神分裂症患者（FE-Sz, n = 26）和中长期慢性精神分裂症患者（Ch-Sz, n =147）。比较各组间RBANS指数评分，进行相关分析和回归分析。我们检查了CHR和HC受试者2年以上的临床结果，rban结构域被用作精神病转化的可能预测因子。在精神病发作后阶段（FE-Sz和Ch-Sz），所有rban结构域的表现都显著受损，rban评分随着疾病进展而下降。回归分析显示，对于CHR和HC受试者，延迟记忆（DM）的基线损害显著预测转化为精神病。此外，部分相关表明，对于FE-Sz和Ch-Sz受试者，DM是唯一与后期精神病相关的。认知缺陷广泛出现，随着疾病进展，功能下降。糖尿病的损害可能是帮助我们理解精神病发展的一个领域。一个关键的需要是监测和治疗精神病患者在疾病的所有阶段的记忆功能。
Cognitive deficits are observed throughout all developmental phases of psychosis. However, prior studies have usually focused on a limited illness period and used a wide variety of cognitive instruments. Therefore, it has been difficult to characterize or highlight cognitive functioning in different stages of psychosis. We administered the RBANS (Repeatable Battery for the Assessment of Neuropsychological Status) tests to 4 participant subgroups, including healthy volunteers (controls, HC, n = 28), subjects at high risk for clinical psychosis (prodrome, CHR, n = 27), first-episode schizophrenia patients (FE-Sz, n = 26), and mid-term and long-term chronic schizophrenia patients (Ch-Sz, n =147). Comparison, correlation, and regression analyses of RBANS index scores were assessed among groups. We examined clinical outcomes over 2 years between the CHR and HC subjects, and RBANS domains were used as possible predictors for conversion to psychosis. Performance on all RBANS domains was significantly impaired during a post-onset stage of psychosis (FE-Sz and Ch-Sz), and RBANS scores declined along with disease progression. Regression analyses showed that for CHR and HC subjects, baseline impairment in delayed memory (DM) significantly predicted conversion to psychosis. Additionally, partial correlations showed that for FE-Sz and Ch-Sz subjects, DM was the only correlate with a later stage of psychosis. Cognitive deficits broadly emerged, and diminished functioning followed along with disease progression. Impairment in DM is perhaps one domain that helps us understand the development of psychosis. A critical need is to monitor and treat memory functioning for psychotic patients throughout all phases of the disease.
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影响因子：
4.5
作者：
Addington J;Cadenhead KS;Cornblatt BA;Mathalon DH;McGlashan TH;Perkins DO;Seidman LJ;Tsuang MT;Walker EF;Woods SW;Addington JA;Cannon TD
通讯作者：
Cannon TD
影响因子：
11.3
作者：
Dougherty, DM;Steinberg, JL;Moeller, FG
通讯作者：
Moeller, FG
影响因子：
17.7
作者：
Brewer, WJ;Francey, SM;McGorry, PD
通讯作者：
McGorry, PD
DOI：
10.5114/aoms.2011.25561
发表时间：
2011-10
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
Cheng Y;Wu W;Wang J;Feng W;Wu X;Li C
通讯作者：
Li C
影响因子：
6.9
作者：
Leeson VC;Robbins TW;Franklin C;Harrison M;Harrison I;Ron MA;Barnes TR;Joyce EM
通讯作者：
Joyce EM