Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20-44 years: the UK National Case-Control Study of Cervical Cancer.
Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20-44 years: the UK National Case-Control Study of Cervical Cancer.
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DOI：
10.1038/sj.bjc.6601296
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发表时间：
2003-12-01
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
我们报告了来自英国国家宫颈癌病例对照研究的20-44岁女性宫颈浸润性鳞状细胞癌和腺癌的危险因素的结果，包括180名腺癌女性，391名鳞状细胞癌女性和923名对照人群。鳞状细胞癌和腺癌的风险与一生中性伴侣的数量密切相关，并且独立地与第一次性交的年龄密切相关。这两种类型的宫颈癌的风险随着口服避孕药使用时间的增加而增加，这种影响在当前和最近口服避孕药的使用者中最为明显。鳞状细胞癌的风险与高产次相关，鳞状细胞癌和腺癌的风险均随首次生育年龄的增加而增加。长期吸烟（20年或以上）与鳞状细胞癌风险增加2倍相关，但吸烟与腺癌风险无关。需要进一步的研究来证实这项研究和其他研究的建议，即宫颈鳞状细胞癌和腺癌之间吸烟相关风险的差异。
We report results on risk factors for invasive squamous cell and adenocarcinomas of the cervix in women aged 20–44 years from the UK National Case–Control Study of Cervical Cancer, including 180 women with adenocarcinoma, 391 women with squamous cell carcinoma and 923 population controls. The risk of both squamous cell and adenocarcinoma was strongly related to the lifetime number of sexual partners, and, independently, to age at first intercourse. The risk of both types of cervical cancer increased with increasing duration of use of oral contraceptives, and this effect was most marked in current and recent users of oral contraceptives. The risk of squamous cell carcinoma was associated with high parity and the risk of both squamous cell and adenocarcinoma increased with early age at first birth. Long duration smoking (20 or more years) was associated with a two-fold increase in the risk of squamous cell carcinoma, but smoking was not associated with the risk of adenocarcinoma. Further studies are needed to confirm the suggestion from this and other studies of differences in risk related to smoking between squamous cell and adenocarcinomas of the cervix.
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影响因子：
9.8
作者：
Altekruse, SF;Lacey, JV;Hildesheim, A
通讯作者：
Hildesheim, A
影响因子：
4.7
作者：
KORHONEN, MO
通讯作者：
KORHONEN, MO
影响因子：
8.8
作者：
通讯作者：
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影响因子：
8.8
作者：
Hildesheim A;Herrero R;Castle PE;Wacholder S;Bratti MC;Sherman ME;Lorincz AT;Burk RD;Morales J;Rodriguez AC;Helgesen K;Alfaro M;Hutchinson M;Balmaceda I;Greenberg M;Schiffman M
通讯作者：
Schiffman M
影响因子：
8.4
作者：
Andersson, S;Rylander, E;Wilander, E
通讯作者：
Wilander, E