Partial volume correction in quantitative amyloid imaging.
Partial volume correction in quantitative amyloid imaging.
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DOI：
10.1016/j.neuroimage.2014.11.058
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发表时间：
2015-02-15
期刊：
影响因子：
5.7
通讯作者：
Dominantly Inherited Alzheimer Network
中科院分区：
文献类型：
--
作者：
Su Y;Blazey TM;Snyder AZ;Raichle ME;Marcus DS;Ances BM;Bateman RJ;Cairns NJ;Aldea P;Cash L;Christensen JJ;Friedrichsen K;Hornbeck RC;Farrar AM;Owen CJ;Mayeux R;Brickman AM;Klunk W;Price JC;Thompson PM;Ghetti B;Saykin AJ;Sperling RA;Johnson KA;Schofield PR;Buckles V;Morris JC;Benzinger TLS;Dominantly Inherited Alzheimer Network
淀粉样蛋白成像是一种有价值的工具，在痴呆症的研究和诊断。由于正电子发射断层扫描（PET）扫描仪具有有限的空间分辨率，测量信号被部分体积效应扭曲。已经提出了各种技术来校正部分容积效应，但是对于这些技术在淀粉样蛋白成像中是否必要以及如果必要，它们应该如何实施还没有达成共识。我们使用模拟和人体匹兹堡化合物B（PiB）PET成像数据评估了双组分部分容积校正技术和区域扩散函数技术。这两种校正技术补偿了部分容积效应，并改善了对PiB保留的细微变化的检测。然而，区域扩展函数技术在应用于模拟数据时更准确。由于PiB保留估计取决于校正技术，因此有必要进行标准化以比较各组之间的结果。部分体积校正有时被避免，因为它增加了对图像配准和分割中的不准确性的敏感性。然而，我们的研究结果表明，适当的PVC可以提高我们的能力，检测淀粉样蛋白沉积的变化。
Amyloid imaging is a valuable tool for research and diagnosis in dementing disorders. As positron emission tomography (PET) scanners have limited spatial resolution, measured signals are distorted by partial volume effects. Various techniques have been proposed for correcting partial volume effects, but there is no consensus as to whether these techniques are necessary in amyloid imaging, and, if so, how they should be implemented. We evaluated a two-component partial volume correction technique and a regional spread function technique using both simulated and human Pittsburgh compound B (PiB) PET imaging data. Both correction techniques compensated for partial volume effects and yielded improved detection of subtle changes in PiB retention. However, the regional spread function technique was more accurate in application to simulated data. Because PiB retention estimates depend on the correction technique, standardization is necessary to compare results across groups. Partial volume correction has sometimes been avoided because it increases the sensitivity to inaccuracy in image registration and segmentation. However, our results indicate that appropriate PVC may enhance our ability to detect changes in amyloid deposition.
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影响因子：
5.7
作者：
Jovicich J;Czanner S;Han X;Salat D;van der Kouwe A;Quinn B;Pacheco J;Albert M;Killiany R;Blacker D;Maguire P;Rosas D;Makris N;Gollub R;Dale A;Dickerson BC;Fischl B
通讯作者：
Fischl B
影响因子：
14
作者：
Brookmeyer, Ron;Johnson, Elizabeth;Arrighi, H. Michael
通讯作者：
Arrighi, H. Michael
影响因子：
2.3
作者：
Eisenstein, Sarah A.;Koller, Jon M.;Hershey, Tamara
通讯作者：
Hershey, Tamara
影响因子：
6.3
作者：
LOGAN, J;FOWLER, JS;CHRISTMAN, DR
通讯作者：
CHRISTMAN, DR
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B